Overview

  • Product name

    CI 976 (PD 128042)
  • Description

    Potent, selective ACAT inhibitor
  • Alternative names

    • PD 128042
  • Purity

    > 98%
  • CAS Number

    114289-47-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2,2-Dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide
  • Molecular weight

    393.57
  • Molecular formula

    C23H39NO4
  • PubChem identifier

    122327
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 50 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCCCCCCC(C)(C)C(=O)NC1=C(C=C(C=C1OC)OC)OC
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Baba T  et al. A lysophospholipid acyltransferase antagonist, CI-976, creates novel membrane tubules marked by intracellular phospholipase A1 KIAA0725p. Mol Cell Biochem 376:151-61 (2013). Read more (PubMed: 23378048) »
  • Sinz MW  et al. In vitro and in vivo disposition of 2,2-dimethyl-N-(2,4,6-trimethoxyphenyl)dodecanamide (CI-976). Identification of a novel five-carbon cleavage metabolite in rats. Drug Metab Dispos 25:123-30 (1997). Read more (PubMed: 9010639) »
  • Krause BR  et al. In vivo evidence that the lipid-regulating activity of the ACAT inhibitor CI-976 in rats is due to inhibition of both intestinal and liver ACAT. J Lipid Res 34:279-94 (1993). Read more (PubMed: 8429262) »

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