Key features and details
- Potent, selective HDAC inhibitor. Cell-permeable.
- CAS Number: 112522-64-2
- Purity: > 99%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameCI-994, HDAC inhibitor. Cell-permeable.
DescriptionPotent, selective HDAC inhibitor. Cell-permeable.
Biological descriptionPotent, selective HDAC inhibitor (Ki values are 0.41 (HDAC1), 0.75 (HDAC3), 100 (HDAC6), and 100 (HDAC8) μM respectively). Induces histone H3 hyperacetylation, cell differentiation and apoptosis. Inhibits proliferation and modulates G1 cell cycle arrest. Antitumor agent. Active in vivo and in vitro. Orally active. Blood-brain barrier and cell-permeable.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
- Lipid metabolism
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab142098 has not yet been referenced specifically in any publications.