Overview

  • Product name

    CI-994, HDAC inhibitor. Cell-permeable.
  • Description

    Potent, selective HDAC inhibitor. Cell-permeable.
  • Biological description

    Potent, selective HDAC inhibitor (Ki values are 0.41 (HDAC1), 0.75 (HDAC3), 100 (HDAC6), and 100 (HDAC8) μM respectively). Induces histone H3 hyperacetylation, cell differentiation and apoptosis. Inhibits proliferation and modulates G1 cell cycle arrest. Antitumor agent. Active in vivo and in vitro. Orally active. Blood-brain barrier and cell-permeable.
  • Purity

    > 99%
  • CAS Number

    112522-64-2
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Beckers T  et al. Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group. Int J Cancer 121:1138-48 (2007). Read more (PubMed: 17455259) »
  • Loprevite M  et al. In vitro study of CI-994, a histone deacetylase inhibitor, in non-small cell lung cancer cell lines. Oncol Res 15:39-48 (2005). Read more (PubMed: 15839304) »
  • Kraker AJ  et al. Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma. Mol Cancer Ther 2:401-8 (2003). Read more (PubMed: 12700284) »

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