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    ciapin1-antibody-ab154904.pdf

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Cell Biology Apoptosis Intracellular Survivin / IAPs
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Anti-CIAPIN1 antibody (ab154904)

  • Datasheet
  • SDS
Submit a review Submit a question References (3)

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Western blot - Anti-CIAPIN1 antibody (ab154904)
  • Western blot - Anti-CIAPIN1 antibody (ab154904)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CIAPIN1 antibody (ab154904)

Key features and details

  • Rabbit polyclonal to CIAPIN1
  • Suitable for: WB, IHC-P
  • Reacts with: Mouse, Human
  • Isotype: IgG

You may also be interested in

Protein
Product image
Recombinant Human CIAPIN1 protein (denatured) (ab139783)
Secondary
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Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-CIAPIN1 antibody
    See all CIAPIN1 primary antibodies
  • Description

    Rabbit polyclonal to CIAPIN1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-312 of Human CIAPIN1 (Uniprot ID: Q6FI81).

  • Positive control

    • Jurkat, Raji, K562, THP1, HL60, NCI-H929, NIH 3T3, JC and BCL1 whole cell lysates; Human SkHep1 xenograft tissue.
  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.00
    Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 79.99% PBS, 20% Glycerol (glycerin, glycerine)
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Cell Biology
    • Apoptosis
    • Intracellular
    • Survivin / IAPs
    • Cancer
    • Drug resistance
    • MRP-related proteins
    • Cancer
    • Drug resistance
    • P glycoproteins

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Positive Controls

    • Raji whole cell lysate (ab30124)
    • Jurkat whole cell lysate (ab7899)
    • K-562 whole cell lysate (ab7911)
    • THP-1 whole cell lysate (ab7913)
    • HL-60 whole cell lysate (ab7914)
  • Recombinant Protein

    • Recombinant Human CIAPIN1 protein (denatured) (ab139783)
  • Related Products

    • Recombinant Human CIAPIN1 protein (denatured) (ab139783)

Applications

Our Abpromise guarantee covers the use of ab154904 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 34 kDa.
IHC-P 1/100 - 1/1000.

Target

  • Function

    May be required for the maturation of extramitochondrial Fe/S proteins (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
  • Tissue specificity

    Ubiquitously expressed. Highly expressed in heart, liver and pancreas.
  • Sequence similarities

    Belongs to the anamorsin family.
  • Cellular localization

    Cytoplasm. Nucleus.
  • Target information above from: UniProt accession Q6FI81 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 57019 Human
    • Entrez Gene: 109006 Mouse
    • Omim: 608943 Human
    • SwissProt: Q6FI81 Human
    • SwissProt: Q8WTY4 Mouse
    • Unigene: 4900 Human
    • Unigene: 27582 Mouse
    • Unigene: 472546 Mouse
    • Alternative names

      • 2810413N20Rik antibody
      • Anamorsin antibody
      • CIAPIN 1 antibody
      • CIAPIN1 antibody
      • CPIN1_HUMAN antibody
      • Cytokine induced apoptosis inhibitor 1 antibody
      • Cytokine-induced apoptosis inhibitor 1 antibody
      • DRE2 antibody
      • Fe-S cluster assembly protein DRE2 homolog antibody
      • Predicted protein of HQ0915 antibody
      • PRO0915 antibody
      see all

    Images

    • Western blot - Anti-CIAPIN1 antibody (ab154904)
      Western blot - Anti-CIAPIN1 antibody (ab154904)
      All lanes : Anti-CIAPIN1 antibody (ab154904) at 1/1000 dilution

      Lane 1 : Jurkat whole cell lysate
      Lane 2 : Raji whole cell lysate
      Lane 3 : K562 whole cell lysate
      Lane 4 : THP1 whole cell lysate
      Lane 5 : HL60 whole cell lysate
      Lane 6 : NCI-H929 whole cell lysate

      Lysates/proteins at 30 µg per lane.

      Predicted band size: 34 kDa



      10% SDS PAGE
    • Western blot - Anti-CIAPIN1 antibody (ab154904)
      Western blot - Anti-CIAPIN1 antibody (ab154904)
      All lanes : Anti-CIAPIN1 antibody (ab154904) at 1/3000 dilution

      Lane 1 : NIH 3T3 whole cell lysate
      Lane 2 : JC whole cell lysate
      Lane 3 : BCL1 whole cell lysate

      Lysates/proteins at 30 µg per lane.

      Predicted band size: 34 kDa



      10% SDS PAGE
    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CIAPIN1 antibody (ab154904)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CIAPIN1 antibody (ab154904)
      Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human SkHep1 xenograft tissue labeling CIAPIN1 with ab154904 at 1/500 dilution.

    Protocols

    • Western blot protocols
    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (3)

    Publishing research using ab154904? Please let us know so that we can cite the reference in this datasheet.

    ab154904 has been referenced in 3 publications.

    • Zheng J  et al. MiRNA-195-5p Functions as a Tumor Suppressor and a Predictive of Poor Prognosis in Non-small Cell Lung Cancer by Directly Targeting CIAPIN1. Pathol Oncol Res N/A:N/A (2019). PubMed: 30637589
    • Chen X  et al. Andrographolide Suppresses MV4-11 Cell Proliferation through the Inhibition of FLT3 Signaling, Fatty Acid Synthesis and Cellular Iron Uptake. Molecules 22:N/A (2017). PubMed: 28858244
    • Wang JH  et al. Upregulation of microRNA-143 reverses drug resistance in human breast cancer cells via inhibition of cytokine-induced apoptosis inhibitor 1. Oncol Lett 13:4695-4700 (2017). WB . PubMed: 28588724

    Customer reviews and Q&As

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