Anti-CIB1/KIP antibody (ab191516)
Key features and details
- Rabbit polyclonal to CIB1/KIP
- Suitable for: WB
- Reacts with: Rat, Human
- Isotype: IgG
Overview
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Product name
Anti-CIB1/KIP antibody
See all CIB1/KIP primary antibodies -
Description
Rabbit polyclonal to CIB1/KIP -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Rat, Human -
Immunogen
Synthetic peptide within Human CIB1/KIP. The exact sequence is proprietary.
Database link: Q99828 -
Positive control
- HEK293T, H9C2, Rat brain lysates
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
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Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituents: 49% PBS, 50% Glycerol -
Concentration information loading...
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Purity
Immunogen affinity purified -
Purification notes
purity is > 95% (by SDS-PAGE) -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab191516 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500. Predicted molecular weight: 22 kDa.
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Notes |
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WB
1/500. Predicted molecular weight: 22 kDa. |
Target
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Function
May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. -
Tissue specificity
Ubiquitous. -
Sequence similarities
Contains 2 EF-hand domains. -
Cellular localization
Membrane. Cytoplasm. Nucleus. Cell projection > filopodium. Apical cell membrane. Localizes to the perinuclear region in the presence of NBR1. Colocalizes with TAS1R2 in apical regions of taste receptor cells. - Information by UniProt
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Database links
- Entrez Gene: 10519 Human
- Entrez Gene: 81823 Rat
- Omim: 602293 Human
- SwissProt: Q99828 Human
- SwissProt: Q9R010 Rat
- Unigene: 715556 Human
- Unigene: 833 Rat
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Alternative names
- Calcium and integrin binding 1 (calmyrin) antibody
- Calcium and integrin binding protein 1 antibody
- Calcium and integrin-binding protein 1 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab191516 has not yet been referenced specifically in any publications.