Overview

  • Product name

  • Description

    Rabbit polyclonal to CIB1/KIP
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human CIB1/KIP (internal sequence). The exact sequence is proprietary.
    Database link: Q99828

  • Positive control

    • Human cervical cancer tissue, Human colon cancer tissue,
  • General notes

     This product was previously labelled as CIB1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab198845 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/40 - 1/200.

Target

  • Function

    May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling.
  • Tissue specificity

    Ubiquitous.
  • Sequence similarities

    Contains 2 EF-hand domains.
  • Cellular localization

    Membrane. Cytoplasm. Nucleus. Cell projection > filopodium. Apical cell membrane. Localizes to the perinuclear region in the presence of NBR1. Colocalizes with TAS1R2 in apical regions of taste receptor cells.
  • Information by UniProt
  • Database links

  • Alternative names

    • Calcium and integrin binding 1 (calmyrin) antibody
    • Calcium and integrin binding protein 1 antibody
    • Calcium and integrin-binding protein 1 antibody
    • Calcium- and integrin-binding protein antibody
    • Calmyrin antibody
    • CIB antibody
    • CIB1 antibody
    • CIB1_HUMAN antibody
    • CIBP antibody
    • DNA PKcs interacting protein antibody
    • DNA-dependent protein kinase interacting protein antibody
    • DNA-PK interaction protein antibody
    • DNA-PKcs-interacting protein antibody
    • Human Snk interacting protein 2 to 28 mRNA complete cds antibody
    • Kinase interacting protein antibody
    • Kinase-interacting protein 1 antibody
    • Kinase-interacting protein antibody
    • KIP antibody
    • KIP1 antibody
    • PRKDCIP antibody
    • SIP2 28 antibody
    • SIP2-28 antibody
    • SNK interacting protein 2 to 28 antibody
    • SNK-interacting protein 2-28 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling CIB1/KIP with ab198845 at 1/40.

  • Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue labeling CIB1/KIP with ab198845 at 1/40.

References

This product has been referenced in:

  • Michel V  et al. CIB2, defective in isolated deafness, is key for auditory hair cell mechanotransduction and survival. EMBO Mol Med 9:1711-1731 (2017). Read more (PubMed: 29084757) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab198845.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up