Overview

  • Product name

  • Description

    Rabbit polyclonal to CIB1/KIP
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human CIB1/KIP aa 50-150 conjugated to keyhole limpet haemocyanin.
    (Peptide available as ab43584, ab43585)

  • Positive control

    • Recombinant Human CIB1/KIP protein (ab78759) can be used as a positive control in WB. This antibody gave a positive signal with recombinant CIB1/KIP protein.
  • General notes

     This product was previously labelled as CIB1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab43133 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 22 kDa (predicted molecular weight: 22 kDa).

Target

  • Function

    May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling.
  • Tissue specificity

    Ubiquitous.
  • Sequence similarities

    Contains 2 EF-hand domains.
  • Cellular localization

    Membrane. Cytoplasm. Nucleus. Cell projection > filopodium. Apical cell membrane. Localizes to the perinuclear region in the presence of NBR1. Colocalizes with TAS1R2 in apical regions of taste receptor cells.
  • Information by UniProt
  • Database links

  • Alternative names

    • Calcium and integrin binding 1 (calmyrin) antibody
    • Calcium and integrin binding protein 1 antibody
    • Calcium and integrin-binding protein 1 antibody
    • Calcium- and integrin-binding protein antibody
    • Calmyrin antibody
    • CIB antibody
    • CIB1 antibody
    • CIB1_HUMAN antibody
    • CIBP antibody
    • DNA PKcs interacting protein antibody
    • DNA-dependent protein kinase interacting protein antibody
    • DNA-PK interaction protein antibody
    • DNA-PKcs-interacting protein antibody
    • Human Snk interacting protein 2 to 28 mRNA complete cds antibody
    • Kinase interacting protein antibody
    • Kinase-interacting protein 1 antibody
    • Kinase-interacting protein antibody
    • KIP antibody
    • KIP1 antibody
    • PRKDCIP antibody
    • SIP2 28 antibody
    • SIP2-28 antibody
    • SNK interacting protein 2 to 28 antibody
    • SNK-interacting protein 2-28 antibody
    see all

Images

  • Anti-CIB1/KIP antibody (ab43133) at 1 µg/ml + Recombinant Human CIB1/KIP protein (ab40628) at 0.1 µg

    Secondary
    Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) (ab65484) at 1/3000 dilution

    Performed under reducing conditions.

    Predicted band size: 22 kDa
    Observed band size: 22 kDa


    Exposure time: 30 seconds

References

ab43133 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab43133.
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