Overview

  • Product name

    Cibenzoline, K channel blocker
  • Description

    ATP-sensitive K channel blocker
  • Alternative names

    • 2-(2,2-diphenylcyclopropyl)-4,5-dihydro-1H-imidazole
    • Cifenline
    • Cipralan
    • Exacor
  • Biological description

    Class IA antiarrhythmic drug. Blocks ATP-sensitive K channels in heart and pancreatic beta cells. Interacts with the channel pore-forming subunit of the K(ATP) channel (Kir6.2) from the cytoplasmic side. Inhibits the delayed rectifier K current [I(Kr)] in sino-atrial node cells.

  • Purity

    > 95%
  • CAS Number

    53267-01-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (±)-2-(2,2-Diphenylcyclopropyl)-2-imidazoline
  • Molecular weight

    262.35
  • Molecular formula

    C18H18N2
  • Storage instructions

    Store at -20°C. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
  • Solubility overview

    Soluble in water to 10 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:

  • Tabuchi Y  et al. Cibenzoline, an ATP-sensitive K(+) channel blocker, binds to the K(+)-binding site from the cytoplasmic side of gastric H(+),K(+)-ATPase. Br J Pharmacol 134:1655-62 (2001). Read more (PubMed: 11739241) »
  • Horie M  et al. Blockade of cardiac ATP-sensitive K+ channel by cibenzoline targets its pore-forming subunit. J Cardiovasc Pharmacol 35:434-42 (2000). Read more (PubMed: 10710130) »
  • Satoh H Comparative actions of cibenzoline and disopyramide on I(Kr) and I(Ks) currents in rat sino-atrial nodal cells. Eur J Pharmacol 407:123-9 (2000). Read more (PubMed: 11050299) »
  • Mukai E  et al. The antiarrhythmic agent cibenzoline inhibits KATP channels by binding to Kir6.2. Biochem Biophys Res Commun 251:477-81 (1998). Read more (PubMed: 9792799) »

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