Overview

  • Product name

  • Description

    Rabbit polyclonal to CIDE A
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human CIDE A aa 181-209 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH).
    Sequence:

    AQVTGQFLIY LGTYMLRVLD DKEERPSLR


    Database link: O60543

  • Positive control

    • Human liver tissue; CEM cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab191193 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000. Predicted molecular weight: 24 kDa.
IHC-P 1/100.

Target

  • Relevance

    Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICARD has been identified as inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE A and CIDE B (for cell death inducing DFF like effector A and B) were recently identified. CIDE contains a new type of domain termed CIDE N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE A induces DNA fragmentation and activates apoptosis, which is inhibited by DFF45. CIDE A is a DFF45 inhibitable effector that promotes cell death and DNA fragmentation. CIDE A is expressed in many tissues.
  • Cellular localization

    Nuclear. Cytoplasm; mitochondrial envelope; lipid droplet.
  • Database links

  • Alternative names

    • Cell death activator CIDE A antibody
    • Cell Death Inducing DFFA Like Effector A antibody
    • cell death inducing DNA fragmentation factor, alpha subunit like effector A antibody
    • CIDE-A antibody
    • CIDEA antibody
    see all

Images

  • Immunohistochemical analysis of paraffin embedded formalin fixed human liver tissue labeling CIDE A using ab191193 at 1/100 dilution.

  • Anti-CIDE A antibody (ab191193) at 1/1000 dilution + CEM cell lysate at 35 µg

    Predicted band size: 24 kDa

References

ab191193 has not yet been referenced specifically in any publications.

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