Anti-CIITA antibody (ab7541)
Key features and details
- Rabbit polyclonal to CIITA
- Isotype: IgG
Overview
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Product name
Anti-CIITA antibody
See all CIITA primary antibodies -
Description
Rabbit polyclonal to CIITA -
Host species
Rabbit -
Immunogen
Synthetic peptide:
CGEIKDNKELPQYLALTTR
conjugated to KLH - which corresponds to a region near the C-terminal end (amino acids 726-742) of the protein encoded by the human CIITA gene.CIITA.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 0.42% Potassium phosphate, 0.87% Sodium chloride -
Concentration information loading... -
Purity
IgG fraction -
Purification notes
This product was prepared from monospecific antiserum by delipidation and defibrination. -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Target
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Function
Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription; the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). -
Involvement in disease
Bare lymphocyte syndrome 2 -
Sequence similarities
Contains 4 LRR (leucine-rich) repeats.
Contains 1 NACHT domain. -
Domain
The acetyltransferase domain is necessary for activation of both class I and class II transcription.
The GTP-binding motif doesn't confer GTPase activity but promotes nuclear localization. -
Post-translational
modificationsAutophosphorylated, affecting interaction with TAF7. -
Cellular localization
Nucleus. Nucleus, PML body. Recruited to PML body by PML. - Information by UniProt
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Alternative names
- C2TA antibody
- C2TA_HUMAN antibody
- CIITA antibody
see all
Datasheets and documents
References
ab7541 has been referenced in 2 publications.
- Christova R et al. P-STAT1 mediates higher-order chromatin remodelling of the human MHC in response to IFNgamma. J Cell Sci 120:3262-70 (2007). WB ; Human . PubMed: 17726060
- Herrmann TL et al. MHC Class II levels and intracellular localization in human dendritic cells are regulated by calmodulin kinase II. J Leukoc Biol 82:686-99 (2007). Flow Cyt . PubMed: 17586661
