Overview

  • Product name

    Cilazapril monohydrate, ACE inhibitor
  • Description

    Potent ACE inhibitor
  • Biological description

    Potent ACE inhibitor (IC50 = 2 nM). Prodrug of cilazaprilat. Inhibits angiotensin II production. Decreases aldosterone driven sodium and water reabsorption. Shows vasodilatory and antihypertensive effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    92077-78-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (4S,7S)-7-[[(2S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]amino]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylic acid monohydrate
  • Molecular weight

    435.51
  • Molecular formula

    C22H31N3O5.H2O
  • PubChem identifier

    56329
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCOC(=O)[C@H](CCC1=CC=CC=C1)N[C@H]2CCCN3CCC[C@H](N3C2=O)C(=O)O.O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Zhang L  et al. The aldosterone receptor antagonist spironolactone prevents peritoneal inflammation and fibrosis. Lab Invest 94:839-50 (2014). Read more (PubMed: 24862968) »
  • Radovic N  et al. Effect of unilateral ureteral obstruction and anti-angiotensin II treatment on renal tubule cell apoptosis and interstitial fibrosis in rats. Coll Antropol 38:583-8 (2014). Read more (PubMed: 25144992) »
  • Knütter I  et al. Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. J Pharmacol Exp Ther 327:432-41 (2008). Read more (PubMed: 18713951) »

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