Overview

  • Product name

    Cilostamide, PDE3 inhibitor
  • Description

    Potent, selective PDE3 inhibitor
  • Biological description

    Potent, selective PDE3 inhibitor (IC50 values are 27 and 50 nM for PDE3A and PDE3B, respectively). Inhibits ADP-induced platelet aggregation (IC50 = 16.8 μM). Antithrombotic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    68550-75-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-Cyclohexyl-4-[(1,2-dihydro-2-oxo-6-quinolinyl)oxy]-N-methylbutanamide
  • Molecular weight

    342.44
  • Molecular formula

    C20H26N2O3
  • PubChem identifier

    2753
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(C1CCCCC1)C(=O)CCCOc2ccc3NC(=O)C=Cc3c2
  • Source

    Synthetic

References

This product has been referenced in:

  • Priem EK  et al. Influence of phosphodiesterases on basal and 5-HT4 receptor facilitated cholinergic contractility in pig descending colon. Eur J Pharmacol 705:156-63 (2013). Read more (PubMed: 23454061) »
  • Sudo T  et al. Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phosphodiesterase isozyme activity. Biochem Pharmacol 59:347-56 (2000). Read more (PubMed: 10644042) »
  • Inoue Y  et al. Suppression of arterial intimal hyperplasia by cilostamide, a cyclic nucleotide phosphodiesterase 3 inhibitor, in a rat balloon double-injury model. Br J Pharmacol 130:231-41 (2000). Read more (PubMed: 10807659) »

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