Cinnabarinic acid, Endogenous mGlu4 selective agonist (ab120506)

Overview

  • Product name

    Cinnabarinic acid, Endogenous mGlu4 selective agonist
  • Description

    Endogenous mGlu4 selective agonist
  • Biological description

    Endogenous selective mGlu4 agonist; generated by autoxidation of the tryptophan metabolite 3-hydroxyanthranilic acid. Activates mGlu4 receptors in transiently transfected HEK293 cells, and is devoid of activity on other mGlu receptor subtypes (mGlu1, 2, 5, 6, 7, and 8). Protects against NMDA-induced excitotoxic cell death.
  • Purity

    > 98%
  • CAS Number

    606-59-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
  • Molecular weight

    300.23
  • Molecular formula

    C14H8N2O6
  • PubChem identifier

    114918
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM (requires warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=C2C(=C1)OC3=CC(=O)C(=C(C3=N2)C(=O)O)N)C(=O)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Fazio F  et al. Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Mol Pharmacol 81:643-56 (2012). Read more (PubMed: 22311707) »
  • Hiramatsu R  et al. Cinnabarinic acid generated from 3-hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase. J Cell Biochem 103:42-53 (2008). Read more (PubMed: 17476692) »
  • Manthey MK  et al. Mechanism of reaction of 3-hydroxyanthranilic acid with molecular oxygen. Biochim Biophys Acta 1034:207-12 (1990). Read more (PubMed: 2162210) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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