Overview

  • Product name

  • Description

    Rabbit polyclonal to Cip4
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human Cip4 aa 276-486.
    Database link: Q15642

  • Positive control

    • IHC-P: Human pancreas and skeletal muscle tissues. ICC/IF: PC-3 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab235913 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.
ICC/IF 1/50 - 1/200.

Target

  • Function

    Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
  • Tissue specificity

    Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea.
  • Sequence similarities

    Belongs to the FNBP1 family.
    Contains 1 FCH domain.
    Contains 1 REM (Hr1) repeat.
    Contains 1 SH3 domain.
  • Post-translational
    modifications

    Tyrosine phosphorylated. Also phosphorylated by PKA.
  • Cellular localization

    Cytoplasm > perinuclear region and Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection > phagocytic cup. Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9.
  • Information by UniProt
  • Database links

  • Alternative names

    • Cdc42 interacting protein 4 antibody
    • Cdc42 interaction protein 4 long isoform antibody
    • Cdc42-interacting protein 4 antibody
    • CG11341 antibody
    • CG15015 PA antibody
    • Cip 4 antibody
    • CIP4 antibody
    • CIP4_HUMAN antibody
    • DCIP4 antibody
    • hSTP antibody
    • Protein Felic antibody
    • Salt tolerant protein antibody
    • Salt tolerator antibody
    • STOT antibody
    • STP antibody
    • Thyroid hormone receptor interactor 10 antibody
    • Thyroid receptor interacting protein 10 antibody
    • Thyroid receptor-interacting protein 10 antibody
    • TR-interacting protein 10 antibody
    • TRIP 10 antibody
    • TRIP-10 antibody
    • trip10 antibody
    • Truncated Cdc42 interaction protein 4 antibody
    see all

Images

  • PC-3 (human prostate adenocarcinoma cell line) cells stained for Cip4 using ab235913 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

  • Paraffin-embedded human skeletal muscle tissue stained for Cip4 with ab235913 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human pancreas tissue stained for Cip4 with ab235913 at 1/100 dilution in immunohistochemical analysis.

References

ab235913 has not yet been referenced specifically in any publications.

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