Key features and details
- GluN2C/GluN2D (formerly NR2C/NR2D) NMDA antagonist
- CAS Number: 684283-16-7
- Soluble in 2 eq. NaOH to 50 mM (with warming)
- Form / State: Solid
- Source: Synthetic
Product namecis-PPDA, GluN2C/GluN2D NMDA antagonist
DescriptionGluN2C/GluN2D (formerly NR2C/NR2D) NMDA antagonist
Potent GluN2C/GluN2D (formerly NR2C / NR2D)-preferring NMDA receptor antagonist. (Ki values for recombinant rat receptors are 0.096 (NR2C), 0.125 (NR2D), 0.55 (NR2A) and 0.31 μM (NR2B)).
Chemical name(2R*,3S*)-1-(Phenanthrenyl-2-carbonyl)piperazine-2,3-dicarboxylic acid
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in 2 eq. NaOH to 50 mM (with warming)
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120047 has been referenced in 5 publications.
- Doyle S et al. Vesicular glutamate release from central axons contributes to myelin damage. Nat Commun 9:1032 (2018). PubMed: 29531223
- Zhang Z & Sun QQ Development of NMDA NR2 subunits and their roles in critical period maturation of neocortical GABAergic interneurons. Dev Neurobiol 71:221-45 (2011). PubMed: 20936660
- Sun QQ & Zhang Z Whisker experience modulates long-term depression in neocortical ?-aminobutyric acidergic interneurons in barrel cortex. J Neurosci Res 89:73-85 (2011). PubMed: 21046566
- Pregno G et al. Neuregulin1/ErbB4-induced migration in ST14A striatal progenitors: calcium-dependent mechanisms and modulation by NMDA receptor activation. BMC Neurosci 12:103 (2011). PubMed: 21991932
- Harney SC et al. Extrasynaptic NR2D-containing NMDARs are recruited to the synapse during LTP of NMDAR-EPSCs. J Neurosci 28:11685-94 (2008). PubMed: 18987204