Overview

  • Product name

    Cisapride, 5-HT4 receptor agonist
  • Description

    5-HT4 receptor agonist. hERG blocker.
  • Biological description

    5-HT4 receptor agonist (EC50 = 140 nM). Potent human ether-a-go-go-related gene (hERG) channel blocker (IC50 = 9.4 nM). Gastrokinetic agent, increases intestinal motility.
  • Purity

    > 99%
  • CAS Number

    81098-60-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Kamiya K  et al. Molecular determinants of hERG channel block by terfenadine and cisapride. J Pharmacol Sci 108:301-7 (2008). Read more (PubMed: 18987434) »
  • Toga T  et al. The 5-HT(4) agonists cisapride, mosapride, and CJ-033466, a Novel potent compound, exhibit different human ether-a-go-go-related gene (hERG)-blocking activities. J Pharmacol Sci 105:207-10 (2007). Read more (PubMed: 17928736) »
  • Barrows B  et al. Extracellular potassium dependency of block of HERG by quinidine and cisapride is primarily determined by the permeant ion and not by inactivation. Channels (Austin) 3:239-48 (0). Read more (PubMed: 19617705) »

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