Key features and details
- Potent, broad spectrum antineoplastic agent
- CAS Number: 15663-27-1
- Soluble in water to 5 mM (with sonication) and in 0.9% w/w NaCl to 5 mM (with sonication)
- Form / State: Solid
- Source: Synthetic
Product nameCisplatin, antineoplastic agent
DescriptionPotent, broad spectrum antineoplastic agent
Potent, broad spectrum antineoplastic agent. Cytotoxic, crosslinks DNA to impair replication and transcription. Arrests cell cycle in G2/M phase. Antitumor, cross-linking and radiation sensitizing agent. Active in vivo and in vitro.
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 5 mM (with sonication) and in 0.9% w/w NaCl to 5 mM (with sonication)
Unstable; make up solutions fresh and use immediately.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141398 has been referenced in 6 publications.
- Mahmood N et al. S-adenosylmethionine in combination with decitabine shows enhanced anti-cancer effects in repressing breast cancer growth and metastasis. J Cell Mol Med 24:10322-10337 (2020). PubMed: 32720467
- Luo R et al. Cisplatin Facilitates Radiation-Induced Abscopal Effects in Conjunction with PD-1 Checkpoint Blockade Through CXCR3/CXCL10-Mediated T-cell Recruitment. Clin Cancer Res 25:7243-7255 (2019). PubMed: 31506388
- Tan Z et al. Environmental stresses induce karyotypic instability in colorectal cancer cells. Mol Biol Cell 30:42-55 (2019). PubMed: 30379607
- Carter RJ et al. Exploring the potential of BH3 mimetic therapy in squamous cell carcinoma of the head and neck. Cell Death Dis 10:912 (2019). PubMed: 31801952
- Qin W et al. Inhibiting microRNA-449 Attenuates Cisplatin-Induced Injury in NRK-52E Cells Possibly via Regulating the SIRT1/P53/BAX Pathway. Med Sci Monit 22:818-23 (2016). PubMed: 26968221
- Black JC et al. Regulation of Transient Site-specific Copy Gain by MicroRNA. J Biol Chem 291:4862-71 (2016). PubMed: 26755726