Overview

  • Product name
    Cisplatin, antineoplastic agent
  • Description
    Potent, broad spectrum antineoplastic agent
  • Biological description
    Potent, broad spectrum antineoplastic agent. Cytotoxic, crosslinks DNA to impair replication and transcription. Arrests cell cycle in G2/M phase. Antitumor, cross-linking and radiation sensitizing agent. Active in vivo and in vitro.

Properties

References

This product has been referenced in:
  • van Gijssel HE  et al. Cisplatin-DNA damage in p21WAF1/Cip1 deficient mouse keratinocytes exposed to cisplatin. Mutagenesis 22:49-54 (2007). Read more (PubMed: 17158520) »
  • Mueller S  et al. Cell-cycle progression and response of germ cell tumors to cisplatin in vitro. Int J Oncol 29:471-9 (2006). Read more (PubMed: 16820891) »
  • Sugimoto C  et al. Apoptosis-promoting gene (bax) transfer potentiates sensitivity of squamous cell carcinoma to cisplatin in vitro and in vivo. Int J Cancer 82:860-7 (1999). Read more (PubMed: 10446454) »
See 1 Publication for this product

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A

Cisplatin

Average
Abreviews
It is difficult to dilute.

Abcam user community

Verified customer

Submitted Feb 27 2018

Answer

There is the possibility of slow ligand-exchange for cisplatin dissolved in water. Our usual advice is to prepare and use solutions on the same day. In this case we strongly suggest that the solution should be used immediately as the product is classed as unstable. Sonicating and gently warming the product for the minimal time for complete solubilisation could actually help because the product will be dissolved more quickly, and therefore have less chance to undergo ligand exchange. There is also the alternative suggestion to dissolve the product in 0.9 % w/w NaCl, which reduces ligand exchange an enhances stability of dissolved cisplatin.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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