Overview

  • Product name

    Citreoviridin A, mitochondrial ATPase inhibitor
  • Description

    Selective mitochondrial ATPase inhibitor
  • Biological description

    Selective mitochondrial ATPase inhibitor (IC50 = 2μM). Induces cell cycle arrest and inhibits proliferation. Mycotoxin.
  • Purity

    > 95%
  • CAS Number

    25425-12-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-[(1E,3E,5E,7E)-8-[(2S,3R,4R,5R)-3,4-Dihydroxy-2,4,5-trimethyloxolan-2-yl]-7-methylocta-1,3,5,7-tetraenyl]-4-methoxy-5-methylpyran-2-one
  • Molecular weight

    402.48
  • Molecular formula

    C23H30O6
  • PubChem identifier

    6436023
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 25 mM and in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1C(C(C(O1)(C)C=C(C)C=CC=CC=CC2=C(C(=CC(=O)O2)OC)C)O)(C)O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Chang HY  et al. Ectopic ATP synthase blockade suppresses lung adenocarcinoma growth by activating the unfolded protein response. Cancer Res 72:4696-706 (2012). Read more (PubMed: 22822083) »
  • Gause EM  et al. Binding of citreoviridin to the beta subunit of the yeast F1-ATPase. J Biol Chem 256:557-9 (1981). Read more (PubMed: 6450205) »
  • Datta SC & Ghosh JJ Effect of citreoviridin, a mycotoxin from Penicillium citreoviride, on kinetic constants of acetylcholinesterase and ATPase in synaptosomes and microsomes from rat brain. Toxicon 19:555-62 (1981). Read more (PubMed: 6460346) »
  • Linnett PE  et al. Citreoviridin, a specific inhibitor of the mitochondiral adenosine triphosphatase. Biochem J 170:503-10 (1978). Read more (PubMed: 148274) »

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