CK 666, Actin polymerization inhibitor (ab141231)
- Datasheet
- References (3)
Overview
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Product nameCK 666, Actin polymerization inhibitor
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DescriptionPotent inhibitor of actin polymerization
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Biological descriptionPotent inhibitor of actin polymerization. Inhibits the Arp2/3 (IC50 = 17 μM), SpArp2/3 (IC50 = 5 μM) and HsArp2/3 complexes (IC50= 4 μM) by preventing a shift into an active conformation.
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Purity> 99%
Properties
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Chemical name2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
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Molecular weight296.34
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Chemical structure
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Molecular formulaC18H17FN2O
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CAS Number442633-00-3
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PubChem identifier589075
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Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
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Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 100 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILESFc1ccccc1C(=O)NCCc2c3ccccc3nc2C
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Source
Synthetic
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Research areas
References
This product has been referenced in:
- Sun SC et al. Arp2/3 complex regulates asymmetric division and cytokinesis in mouse oocytes. PLoS One 6:e18392 (2011). Read more (PubMed: 21494665) »
- Ilatovskaya DV et al. Cortical actin binding protein cortactin mediates ENaC activity via Arp2/3 complex. FASEB J 25:2688-99 (2011). Read more (PubMed: 21536685) »
- Nolen BJ et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature 460:1031-4 (2009). Read more (PubMed: 19648907) »
