CK869, Actin-related protein 2/3 (Arp2/3) complex inhibitor (ab218109)

Overview

  • Product name

    CK869, Actin-related protein 2/3 (Arp2/3) complex inhibitor
  • Description

    Actin-related protein 2/3 (Arp2/3) complex inhibitor
  • Alternative names

    • Actin Assembly Inhibitor XIV
    • CK-0157869
    • CK-869
  • Biological description

    Inhibitor of human and bovine actin-related protein 2/3 (Arp2/3) complex. Inhibits actin polymerization with bovine Arp2/3 complex (IC50 = 11 μM) and inhibits the formation of actin filament comet tails by Listeria monocytogenes in infected SKOV3 cells (IC50 = 7 μM) . Does not inhibit budding or fission yeast Arp2/3 complexes.

  • Purity

    > 98%
  • CAS Number

    388592-44-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-4-thiazolidinone
  • Molecular weight

    394.28
  • Molecular formula

    C17H16BrNO3S
  • PubChem identifier

    3574452
  • Storage instructions

    Shipped at 4°C. Store at +4°C. Store In the Dark.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=CC(=C(C=C1)N2C(SCC2=O)C3=CC(=CC=C3)Br)OC
  • Source

    Synthetic

References

This product has been referenced in:

  • Beckham Y  et al. Arp2/3 inhibition induces amoeboid-like protrusions in MCF10A epithelial cells by reduced cytoskeletal-membrane coupling and focal adhesion assembly. PLoS One 9:e100943 (2014). Read more (PubMed: 24967897) »
  • Ilatovskaya DV  et al. Arp2/3 complex inhibitors adversely affect actin cytoskeleton remodeling in the cultured murine kidney collecting duct M-1 cells. Cell Tissue Res 354:783-92 (2013). Read more (PubMed: 24036843) »
  • Hetrick B  et al. Small molecules CK-666 and CK-869 inhibit actin-related protein 2/3 complex by blocking an activating conformational change. Chem Biol 20:701-12 (2013). Read more (PubMed: 23623350) »
  • Nolen BJ  et al. Characterization of two classes of small molecule inhibitors of Arp2/3 complex. Nature 460:1031-4 (2009). Read more (PubMed: 19648907) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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