Key features and details
- Rabbit polyclonal to CKAP2/LB1
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-CKAP2/LB1 antibody
See all CKAP2/LB1 primary antibodies
DescriptionRabbit polyclonal to CKAP2/LB1
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Fusion protein (GST-tag) corresponding to Human CKAP2/LB1. Full length.
Database link: Q8WWK9
- Human colon cancer and human tonsil tissue.
This product was previously labelled as CKAP2
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab198188 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/50 - 1/200.|
FunctionPossesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner.
Tissue specificityAbundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney.
Sequence similaritiesBelongs to the CKAP2 family.
Developmental stagePresent at the G1/S boundary. Accumulates as cells progress from S to G2 into mitosis. Rapidly degraded during mitosis exit by CDH1-activated anaphase promoting complex/cyclosome (APC/C).
Cellular localizationCytoplasm > cytoskeleton. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > spindle. Cytoplasm > cytoskeleton > spindle pole. Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules.
- Information by UniProt
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ab198188 has been referenced in 1 publication.
- Guo QS et al. Involvement of FAK-ERK2 signaling pathway in CKAP2-induced proliferation and motility in cervical carcinoma cell lines. Sci Rep 7:2117 (2017). IHC-P ; Human . PubMed: 28522860