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    ckap2lb1-antibody-ab198188.pdf

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Cell Biology Cell Cycle Cell Division Spindle
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Anti-CKAP2/LB1 antibody (ab198188)

  • Datasheet
Submit a review Submit a question References (1)

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CKAP2/LB1 antibody (ab198188)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CKAP2/LB1 antibody (ab198188)

Key features and details

  • Rabbit polyclonal to CKAP2/LB1
  • Suitable for: IHC-P
  • Reacts with: Human
  • Isotype: IgG

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Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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Overview

  • Product name

    Anti-CKAP2/LB1 antibody
    See all CKAP2/LB1 primary antibodies
  • Description

    Rabbit polyclonal to CKAP2/LB1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Fusion protein (GST-tag) corresponding to Human CKAP2/LB1. Full length.
    Database link: Q8WWK9

  • Positive control

    • Human colon cancer and human tonsil tissue.
  • General notes

     This product was previously labelled as CKAP2

     

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.4
    Preservative: 0.05% Sodium azide
    Constituents: 49% PBS, 50% Glycerol (glycerin, glycerine)
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Cell Biology
    • Cell Cycle
    • Cell Division
    • Spindle
    • Cell Biology
    • Cell Cycle
    • Cell Division
    • Cytokinesis

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Applications

Our Abpromise guarantee covers the use of ab198188 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200.

Target

  • Function

    Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner.
  • Tissue specificity

    Abundant in testis, thymus, and in tumor derived cell lines, while barely detectable in liver, prostate, and kidney.
  • Sequence similarities

    Belongs to the CKAP2 family.
  • Developmental stage

    Present at the G1/S boundary. Accumulates as cells progress from S to G2 into mitosis. Rapidly degraded during mitosis exit by CDH1-activated anaphase promoting complex/cyclosome (APC/C).
  • Cellular localization

    Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton. Cytoplasm > cytoskeleton > spindle. Cytoplasm > cytoskeleton > spindle pole. Contrary to the ectopically expressed protein, endogenous CKAP2 does not colocalize with microtubules in G1, S and early G2. At late G2 and prophase after separation of duplicated centrosomes, colocalizes with gamma-tubulin and centrosome-proximal microtubules. From prometaphase through anaphase B, colocalizes with mitotic spindle poles and spindle microtubules. During cytokinesis, absent from midbody microtubules.
  • Target information above from: UniProt accession Q8WWK9 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 26586 Human
    • Omim: 611569 Human
    • SwissProt: Q8WWK9 Human
    • Unigene: 444028 Human
    • Unigene: 521482 Human
    • Unigene: 728722 Human
    • Alternative names

      • AI461656 antibody
      • AW228814 antibody
      • CKAP 2 antibody
      • Ckap2 antibody
      • CKAP2_HUMAN antibody
      • CTCL tumor antigen se20 10 antibody
      • CTCL tumor antigen se20-10 antibody
      • Cytoskeleton associated protein 2 antibody
      • Cytoskeleton-associated protein 2 antibody
      • DKFZp686L1238 antibody
      • FLJ10749 antibody
      • LB1 antibody
      • se20 10 antibody
      • TMAP antibody
      • Tumor and microtubule associated protein antibody
      • Tumor associated microtubule associated protein antibody
      • Tumor- and microtubule-associated protein antibody
      see all

    Images

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CKAP2/LB1 antibody (ab198188)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CKAP2/LB1 antibody (ab198188)

      Immunohistochemical analysis of formalin fixed paraffin embedded human tonsil tissue labeling CKAP2/LB1 with ab198188 at 1/70

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CKAP2/LB1 antibody (ab198188)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CKAP2/LB1 antibody (ab198188)

      Immunohistochemical analysis of formalin fixed paraffin embedded human colon cancer labeling CKAP2/LB1 with ab198188 at 1/70

    Protocols

    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
  • References (1)

    Publishing research using ab198188? Please let us know so that we can cite the reference in this datasheet.

    ab198188 has been referenced in 1 publication.

    • Guo QS  et al. Involvement of FAK-ERK2 signaling pathway in CKAP2-induced proliferation and motility in cervical carcinoma cell lines. Sci Rep 7:2117 (2017). IHC-P ; Human . PubMed: 28522860

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