CKI-7 dihydrochloride, Casein kinase 1 inhibitor (ab143760)

Overview

  • Product name

    CKI-7 dihydrochloride, Casein kinase 1 inhibitor
  • Description

    Casein kinase 1 inhibitor. Water soluble analog of CKI-7.
  • Biological description

    Casein kinase 1 inhibitor. Water soluble analog of CKI-7 (ab143759). Inhibits SGK, S6K1 and MSK1. Induces retinal cell differentiation. Phosphorylates the inner dynein arm I1 Intermediate Chain.
  • CAS Number

    1177141-67-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-(2-Aminoethyl)-5-chloroisoquinoline-8-sulfonamide dihydrochloride
  • Molecular weight

    358.67
  • Molecular formula

    C11H12ClN3O2S.2HCl
  • PubChem identifier

    16078955
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 10 mM and in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=C2C=CN=CC2=C1S(=O)(=O)NCCN)Cl.Cl.Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Peifer C  et al. 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta. J Med Chem 52:7618-30 (2009). Read more (PubMed: 19591487) »
  • Osakada F  et al. In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction. J Cell Sci 122:3169-79 (2009). Read more (PubMed: 19671662) »
  • Rena G  et al. D4476, a cell-permeant inhibitor of CK1, suppresses the site-specific phosphorylation and nuclear exclusion of FOXO1a. EMBO Rep 5:60-5 (2004). Read more (PubMed: 14710188) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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