CL-316243 disodium salt, adrenergic-beta3 receptor agonist (ab144605)

Overview

  • Product name

    CL-316243 disodium salt, adrenergic-beta3 receptor agonist
  • Description

    Selective adrenergic-β3 receptor agonist
  • Biological description

    Selective adrenergic-β3 receptor agonist. Induces adipose tissue remodelling in rat. Hypoglycemic agent. Active in vivo and in vitro.
  • Purity

    > 99%
  • CAS Number

    151126-84-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-[(2R)-2-[[(2R)-2-(3-Chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylic acid disodium salt
  • Molecular weight

    465.80
  • Molecular formula

    C20H18ClNNa2O7
  • PubChem identifier

    5312115
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(CC1=CC2=C(C=C1)OC(O2)(C(=O)[O-])C(=O)[O-])NCC(C3=CC(=CC=C3)Cl)O.[Na+].[Na+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Navegantes LC  et al. CL 316,243, a selective beta3-adrenergic agonist, inhibits protein breakdown in rat skeletal muscle. Pflugers Arch 451:617-24 (2006). Read more (PubMed: 16091956) »
  • Ferrand C  et al. Prolonged treatment with the beta3-adrenergic agonist CL 316243 induces adipose tissue remodeling in rat but not in guinea pig: 1) fat store depletion and desensitization of beta-adrenergic responses. J Physiol Biochem 62:89-99 (2006). Read more (PubMed: 17217163) »
  • Bahl AK  et al. Comparison of the profiles of agonists as stimulants of the beta 3-adrenoceptor in vitro with their gastroprotective effects in the conscious rat. Br J Pharmacol 117:580-586 (1996). Read more (PubMed: 8821552) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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