Overview

  • Product name

    clasto-Lactacystin beta-lactone, 20S proteasome inhibitor
  • Description

    Potent, irreversible and cell-permeable 20S proteasome inhibitor
  • Biological description

    Potent, irreversible and cell-permeable 20S proteasome inhibitor (IC50 = 50 nM). Active metabolite of lactacystin (ab141411). Inhibits cell-cycle progression in cancer cells. Antitumor agent. Active in vivo and in vitro.
  • Purity

    > 95%
  • CAS Number

    154226-60-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Radjasa OK  et al. Highlights of marine invertebrate-derived biosynthetic products: their biomedical potential and possible production by microbial associants. Bioorg Med Chem 19:6658-74 (2011). Read more (PubMed: 21835627) »
  • Zandy AJ & Bassnett S Proteolytic mechanisms underlying mitochondrial degradation in the ocular lens. Invest Ophthalmol Vis Sci 48:293-302 (2007). Read more (PubMed: 17197546) »
  • Dick LR  et al. Mechanistic studies on the inactivation of the proteasome by lactacystin: a central role for clasto-lactacystin beta-lactone. J Biol Chem 271:7273-6 (1996). Read more (PubMed: 8631740) »

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