Key features and details
- Potent, irreversible and cell-permeable 20S proteasome inhibitor
- CAS Number: 154226-60-5
- Purity: > 95%
- Soluble in DMSO to 75 mM and in water to 10 mM
- Form / State: Solid
- Source: Synthetic
Product nameclasto-Lactacystin beta-lactone, 20S proteasome inhibitor
DescriptionPotent, irreversible and cell-permeable 20S proteasome inhibitor
Biological descriptionPotent, irreversible and cell-permeable 20S proteasome inhibitor (IC50 = 50 nM). Active metabolite of lactacystin (ab141411). Inhibits cell-cycle progression in cancer cells. Antitumor agent. Active in vivo and in vitro.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 75 mM and in water to 10 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab141412 has been referenced in 1 publication.
- Kajiho H et al. CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum. Sci Rep 9:13152 (2019). PubMed: 31511573