Anti-Clathrin heavy chain antibody (ab21679)

Rabbit polyclonal Clathrin heavy chain antibody. Validated in WB, IP, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Hamster, Human. Cited in 59 publication(s). Independently reviewed in 33 review(s).

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ab21679 has been referenced in 62 publications.

  • Villella VR  et al. A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease. EMBO J 38:N/A (2019). PubMed: 30498130
  • Rivera-Serrano EE  et al. Cellular entry and uncoating of naked and quasi-enveloped human hepatoviruses. Elife 8:N/A (2019). PubMed: 30801249
  • Almada P  et al. Automating multimodal microscopy with NanoJ-Fluidics. Nat Commun 10:1223 (2019). PubMed: 30874553
  • Sorkina T  et al. Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter. Elife 7:N/A (2018). PubMed: 29630493
  • Evergren E  et al. Eps15R and clathrin regulate EphB2-mediated cell repulsion. Traffic 19:44-57 (2018). PubMed: 28972287
  • Wenzel EM  et al. Concerted ESCRT and clathrin recruitment waves define the timing and morphology of intraluminal vesicle formation. Nat Commun 9:2932 (2018). PubMed: 30050131
  • Torri A  et al. Extracellular MicroRNA Signature of Human Helper T Cell Subsets in Health and Autoimmunity. J Biol Chem 292:2903-2915 (2017). PubMed: 28077577
  • Soykan T  et al. Synaptic Vesicle Endocytosis Occurs on Multiple Timescales and Is Mediated by Formin-Dependent Actin Assembly. Neuron 93:854-866.e4 (2017). PubMed: 28231467
  • Simsek D  et al. The Mammalian Ribo-interactome Reveals Ribosome Functional Diversity and Heterogeneity. Cell 169:1051-1065.e18 (2017). PubMed: 28575669
  • Poulsen ET  et al. An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients. Front Mol Neurosci 10:59 (2017). ICC/IF . PubMed: 28360834
  • Halamoda-Kenzaoui B  et al. The agglomeration state of nanoparticles can influence the mechanism of their cellular internalisation. J Nanobiotechnology 15:48 (2017). WB ; Human . PubMed: 28651541
  • Niu Y  et al. Ablation of SNX6 leads to defects in synaptic function of CA1 pyramidal neurons and spatial memory. Elife 6:N/A (2017). PubMed: 28134614
  • Briens A  et al. Astrocytes regulate the balance between plasminogen activation and plasmin clearance via cell-surface actin. Cell Discov 3:17001 (2017). ICC . PubMed: 28417010
  • Martin PM  et al. Schwannomin-interacting Protein 1 Isoform IQCJ-SCHIP1 Is a Multipartner Ankyrin- and Spectrin-binding Protein Involved in the Organization of Nodes of Ranvier. J Biol Chem 292:2441-2456 (2017). PubMed: 27979964
  • Fehlinger A  et al. Prion strains depend on different endocytic routes for productive infection. Sci Rep 7:6923 (2017). PubMed: 28761068
  • Khushi M  et al. Automated classification and characterization of the mitotic spindle following knockdown of a mitosis-related protein. BMC Bioinformatics 18:566 (2017). PubMed: 29297284
  • Chang TY  et al. Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. Elife 6:N/A (2017). PubMed: 29271742
  • Chandrasekaran R  et al. Clostridium difficile Toxin A Undergoes Clathrin-Independent, PACSIN2-Dependent Endocytosis. PLoS Pathog 12:e1006070 (2016). WB, IF . PubMed: 27942025
  • Pal K  et al. Smoothened determines ß-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium. J Cell Biol 212:861-75 (2016). PubMed: 27002170
  • Yin X  et al. Distinct Entry Mechanisms for Nonenveloped and Quasi-Enveloped Hepatitis E Viruses. J Virol 90:4232-42 (2016). PubMed: 26865708
  • Rao SR  et al. The Clathrin-dependent Spindle Proteome. Mol Cell Proteomics 15:2537-53 (2016). PubMed: 27174698
  • Chang HF  et al. Endocytosis of Cytotoxic Granules Is Essential for Multiple Killing of Target Cells by T Lymphocytes. J Immunol 197:2473-84 (2016). PubMed: 27527597
  • Hung WS  et al. Disabled-2 is a negative immune regulator of lipopolysaccharide-stimulated Toll-like receptor 4 internalization and signaling. Sci Rep 6:35343 (2016). PubMed: 27748405
  • Valley CC  et al. Sequential superresolution imaging of multiple targets using a single fluorophore. PLoS One 10:e0123941 (2015). PubMed: 25860558
  • Burgess SG  et al. Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly. PLoS Genet 11:e1005345 (2015). PubMed: 26134678
  • Gimber N  et al. Diffusional spread and confinement of newly exocytosed synaptic vesicle proteins. Nat Commun 6:8392 (2015). PubMed: 26399746
  • Padmanabhan R & Taneyhill LA Cadherin-6B undergoes macropinocytosis and clathrin-mediated endocytosis during cranial neural crest cell EMT. J Cell Sci 128:1773-86 (2015). PubMed: 25795298
  • Naik RJ  et al. Exogenous chondroitin sulfate glycosaminoglycan associate with arginine-rich peptide-DNA complexes to alter their intracellular processing and gene delivery efficiency. Biochim Biophys Acta 1848:1053-64 (2015). ICC/IF ; Chinese hamster . PubMed: 25637297
  • Chen D  et al. Glioma cell proliferation controlled by ERK activity-dependent surface expression of PDGFRA. PLoS One 9:e87281 (2014). ICC/IF ; Human . PubMed: 24489888
  • Stahlschmidt W  et al. Clathrin terminal domain-ligand interactions regulate sorting of mannose 6-phosphate receptors mediated by AP-1 and GGA adaptors. J Biol Chem 289:4906-18 (2014). ICC/IF . PubMed: 24407285
  • Vassilopoulos S  et al. Actin scaffolding by clathrin heavy chain is required for skeletal muscle sarcomere organization. J Cell Biol 205:377-93 (2014). PubMed: 24798732
  • Pang HB  et al. An endocytosis pathway initiated through neuropilin-1 and regulated by nutrient availability. Nat Commun 5:4904 (2014). PubMed: 25277522
  • Watanabe S  et al. Clathrin regenerates synaptic vesicles from endosomes. Nature 515:228-33 (2014). PubMed: 25296249
  • Wiernasz E  et al. Ttyh1 protein is expressed in glia in vitro and shows elevated expression in activated astrocytes following status epilepticus. Neurochem Res 39:2516-26 (2014). WB, ICC, IHC ; Rat . PubMed: 25316497
  • Bitsikas V  et al. Clathrin-independent pathways do not contribute significantly to endocytic flux. Elife 3:e03970 (2014). PubMed: 25232658
  • Koral K  et al. Akt recruits Dab2 to albumin endocytosis in the proximal tubule. Am J Physiol Renal Physiol 307:F1380-9 (2014). PubMed: 25253241
  • Azab W  et al. Glycoprotein H and a4ß1 integrins determine the entry pathway of alphaherpesviruses. J Virol 87:5937-48 (2013). PubMed: 23514881
  • Watson PM  et al. Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitro models of the rat blood-brain barrier and blood-spinal cord barrier. BMC Neurosci 14:59 (2013). ICC/IF ; Rat . PubMed: 23773766
  • Philippe M  et al. Discs large 1 (Dlg1) scaffolding protein participates with clathrin and adaptator protein complex 1 (AP-1) in forming Weibel-Palade bodies of endothelial cells. J Biol Chem 288:13046-56 (2013). Human . PubMed: 23532850
  • Krishnan M  et al. Mycoplasma pneumoniae CARDS toxin is internalized via clathrin-mediated endocytosis. PLoS One 8:e62706 (2013). WB ; Human . PubMed: 23667510
  • Wahl S  et al. A local, periactive zone endocytic machinery at photoreceptor synapses in close vicinity to synaptic ribbons. J Neurosci 33:10278-300 (2013). PubMed: 23785143
  • Svensson KJ  et al. Exosome uptake depends on ERK1/2-heat shock protein 27 signaling and lipid Raft-mediated endocytosis negatively regulated by caveolin-1. J Biol Chem 288:17713-24 (2013). PubMed: 23653359
  • Zhao Z  et al. S-nitrosylation of ARH is required for LDL uptake by the LDL receptor. J Lipid Res 54:1550-9 (2013). PubMed: 23564733
  • Yao J  et al. Loss of the SV2-like protein SVOP produces no apparent deficits in laboratory mice. PLoS One 8:e68215 (2013). WB ; Mouse . PubMed: 23894296
  • Puri C  et al. Diverse autophagosome membrane sources coalesce in recycling endosomes. Cell 154:1285-99 (2013). PubMed: 24034251
  • Larson CL  et al. Coxiella burnetii effector protein subverts clathrin-mediated vesicular trafficking for pathogen vacuole biogenesis. Proc Natl Acad Sci U S A 110:E4770-9 (2013). PubMed: 24248335
  • Janssen SF  et al. In silico analysis of the molecular machinery underlying aqueous humor production: potential implications for glaucoma. J Clin Bioinforma 3:21 (2013). PubMed: 24165276
  • Lacruz RS  et al. Adaptor protein complex 2 (AP-2) mediated, clathrin dependent endocytosis, and related gene activities, are a prominent feature during maturation stage amelogenesis. J Bone Miner Res : (2012). PubMed: 23044750
  • Rao A  et al. Epitope-tagged dopamine transporter knock-in mice reveal rapid endocytic trafficking and filopodia targeting of the transporter in dopaminergic axons. FASEB J : (2012). PubMed: 22267337
  • Scharadin TM  et al. TIG3 Tumor Suppressor-Dependent Organelle Redistribution and Apoptosis in Skin Cancer Cells. PLoS One 6:e23230 (2011). ICC/IF ; Human . PubMed: 21858038
  • Gautier JJ  et al. Clathrin is required for Scar/Wave-mediated lamellipodium formation. J Cell Sci 124:3414-27 (2011). PubMed: 22010197
  • Jones SA  et al. Fast, three-dimensional super-resolution imaging of live cells. Nat Methods 8:499-508 (2011). PubMed: 21552254
  • Neumann-Staubitz P  et al. Characterization of a temperature-sensitive vertebrate clathrin heavy chain mutant as a tool to study clathrin-dependent events in vivo. PLoS One 5:e12017 (2010). WB . PubMed: 20700507
  • Peng M  et al. Endocytosis of FcalphaR is clathrin and dynamin dependent, but its cytoplasmic domain is not required. Cell Res 20:223-37 (2010). PubMed: 19859085
  • Wu CY  et al. Mammalian expression of virus-like particles for advanced mimicry of authentic influenza virus. PLoS One 5:e9784 (2010). WB . PubMed: 20339535
  • Molla-Herman A  et al. The ciliary pocket: an endocytic membrane domain at the base of primary and motile cilia. J Cell Sci 123:1785-95 (2010). WB ; Human . PubMed: 20427320
  • Gerner C  et al. Indications for cell stress in response to adenoviral and baculoviral gene transfer observed by proteome profiling of human cancer cells. Electrophoresis 31:1822-32 (2010). WB ; Human . PubMed: 20446292
  • Källquist L  et al. Neutrophil elastase and proteinase 3 trafficking routes in myelomonocytic cells. Exp Cell Res 316:3182-96 (2010). ICC/IF ; Human . PubMed: 20828556
  • Di Michele M  et al. A proteomic approach to paclitaxel chemoresistance in ovarian cancer cell lines. Biochim Biophys Acta 1794:225-36 (2009). PubMed: 18973835
  • Borlido J  et al. Clathrin is spindle-associated but not essential for mitosis. PLoS ONE 3:e3115 (2008). WB, ICC/IF ; Human . PubMed: 18769625
  • Bergami M  et al. Uptake and recycling of pro-BDNF for transmitter-induced secretion by cortical astrocytes. J Cell Biol 183:213-21 (2008). IHC-FoFr ; Rat . PubMed: 18852301
  • Deora A  et al. Transmembrane TNF-dependent uptake of anti-TNF antibodies. MAbs 9:680-695 (0). PubMed: 28323513

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