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    claudin-10-antibody-ab24792.pdf

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Signal Transduction Cytoskeleton / ECM Cell Adhesion Cell Adhesion Molecules Endothelial
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Anti-Claudin 10 antibody (ab24792)

  • Datasheet
  • SDS
Submit a review Submit a question References (5)

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Key features and details

  • Rabbit polyclonal to Claudin 10
  • Suitable for: IHC-P
  • Reacts with: Human
  • Isotype: IgG

You may also be interested in

Protein
Product image
Recombinant Human Claudin 10 protein (ab152945)
Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

View more associated products

Overview

  • Product name

    Anti-Claudin 10 antibody
    See all Claudin 10 primary antibodies
  • Description

    Rabbit polyclonal to Claudin 10
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide within Human Claudin 10 aa 200 to the C-terminus (C terminal). The exact sequence is proprietary.
    Database link: P78369

  • General notes

    This product is FOR RESEARCH USE ONLY. For commercial use, please contact partnerships@abcam.com.

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

    One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

    Learn more here.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    pH: 7.60
    Preservative: 0.1% Sodium azide
    Constituents: PBS, 1% BSA
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Signal Transduction
    • Cytoskeleton / ECM
    • Cell Adhesion
    • Cell Adhesion Molecules
    • Endothelial
    • Signal Transduction
    • Cytoskeleton / ECM
    • Cell Adhesion
    • Gap Junctions

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Recombinant Protein

    • Recombinant Human Claudin 10 protein (ab152945)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab24792 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
1/50. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
Notes
IHC-P
1/50. Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

Target

  • Function

    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
  • Sequence similarities

    Belongs to the claudin family.
  • Cellular localization

    Cell junction > tight junction. Cell membrane.
  • Target information above from: UniProt accession P78369 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 9071 Human
    • Entrez Gene: 58187 Mouse
    • SwissProt: P78369 Human
    • SwissProt: Q5W075 Human
    • SwissProt: Q6IBF9 Human
    • SwissProt: Q96N78 Human
    • SwissProt: Q8VC62 Mouse
    • SwissProt: Q9Z0S6 Mouse
    • Unigene: 534377 Human
    • Unigene: 656580 Human
    see all
  • Alternative names

    • Claudin-10 antibody
    • Claudin10 antibody
    • CLD10_HUMAN antibody
    • CLDN 10 antibody
    • CLDN10 antibody
    • CLDN10 protein antibody
    • CPETRL 3 antibody
    • CPETRL3 antibody
    • HGNC:2033 antibody
    • OSP L antibody
    • OSP like protein antibody
    • OSP-like protein antibody
    • OSPL antibody
    see all

Protocols

  • Immunohistochemistry protocols

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download

References (5)

Publishing research using ab24792? Please let us know so that we can cite the reference in this datasheet.

ab24792 has been referenced in 5 publications.

  • Zhang X  et al. CLDN10 promotes a malignant phenotype of osteosarcoma cells via JAK1/Stat1 signaling. J Cell Commun Signal N/A:N/A (2019). PubMed: 30796717
  • Chae MC  et al. Prognostic significance of claudin 4 in completely resected adenocarcinoma of the lung. Korean J Thorac Cardiovasc Surg 47:262-8 (2014). IHC . PubMed: 25207224
  • Kirk A  et al. Differential expression of claudin tight junction proteins in the human cortical nephron. Nephrol Dial Transplant 25:2107-19 (2010). IHC-Fr ; Human . PubMed: 20124215
  • Dubé E  et al. Alterations in gene expression in the caput epididymides of nonobstructive azoospermic men. Biol Reprod 78:342-51 (2008). PubMed: 17928628
  • Hermo L  et al. Structural alterations of epididymal epithelial cells in cathepsin A-deficient mice affect the blood-epididymal barrier and lead to altered sperm motility. J Androl 28:784-97 (2007). PubMed: 17522420

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