Product nameAnti-Claudin 7 / CLDN-7 antibody - Cocktail of mouse monoclonal and rabbit polyclonal, prediluted
See all Claudin 7 / CLDN-7 primary antibodies
DescriptionRabbit polyclonal to Claudin 7 / CLDN-7 - Cocktail of mouse monoclonal and rabbit polyclonal, prediluted
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Cow, Dog, Pig
Synthetic peptide corresponding to Human Claudin 7/ CLDN-7 (C terminal).
Database link: O95471
- IHC-P: Human colon carcinoma tissue.
For manual IHC only.
Previously labelled as Claudin 7.
Storage instructionsShipped at 4°C. Store at +4°C. Do Not Freeze.
Storage bufferpH: 7.60
Preservative: 0.099% Sodium azide
Constituents: 1% BSA, Tris buffered saline
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab27488 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Ready to use.
Boil tissue section in Citrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min.
Primary antibody incubation for 10 minutes at room temperature.
FunctionPlays a major role in tight junction-specific obliteration of the intercellular space.
Tissue specificityExpressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
Sequence similaritiesBelongs to the claudin family.
Cellular localizationCell membrane. Lateral cell membrane. Cell junction > tight junction. Co-localizes with EPCAM at the lateral cell membrane and tight junction.
- Information by UniProt
- CEPTR L2 antibody
- CEPTRL 2 antibody
- CEPTRL2 antibody
ab27488 has not yet been referenced specifically in any publications.