Recombinant
RabMAb

Anti-Claudin 8 antibody [EPR12680(2)] (ab183738)

Overview

  • Product name
    Anti-Claudin 8 antibody [EPR12680(2)]
    See all Claudin 8 primary antibodies
  • Description
    Rabbit monoclonal [EPR12680(2)] to Claudin 8
  • Host species
    Rabbit
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Claudin 8 aa 200 to the C-terminus. The exact sequence is proprietary.
    Database link: P56748

  • Positive control
    • Human colon and Human colonic adenocarcinoma tissue.
  • General notes

     

     

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents

    This product is a recombinant rabbit monoclonal antibody.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.01% Sodium azide
    Constituents: 59% PBS, 40% Glycerol, 0.05% BSA
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Monoclonal
  • Clone number
    EPR12680(2)
  • Isotype
    IgG
  • Research areas

Associated products

Applications

Our Abpromise guarantee covers the use of ab183738 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/500 - 1/1000.

Target

  • Function
    Plays a major role in tight junction-specific obliteration of the intercellular space.
  • Tissue specificity
    Expressed in the epididymis, mainly in the caput segment.
  • Sequence similarities
    Belongs to the claudin family.
  • Cellular localization
    Cell junction > tight junction. Cell membrane. Localizes to tight junctions in all 3 segments of the epididymis, in the caput found in the lateral margins of principal cells, and in the corpus at the interface between basal and principal cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • Claudin 8 antibody
    • Claudin-8 antibody
    • CLD8_HUMAN antibody
    • Cldn8 antibody
    • Epididymis secretory protein Li 79 antibody
    • HEL S 79 antibody
    • OTTHUMP00000101915 antibody
    see all

Images

  • Immunohistochemical analysis of paraffin-embedded Human colon tissue labeling Claudin 8 with ab183738 at 1/1000 dilution. Counter stain Hematoxylin.

  • Immunohistochemical analysis of paraffin-embedded Human colonic adenocarcinoma tissue labeling Claudin 8 with ab183738 at 1/1000 dilution. Counter stain Hematoxylin.

References

This product has been referenced in:
  • Ashikari D  et al. CLDN8, an androgen-regulated gene, promotes prostate cancer cell proliferation and migration. Cancer Sci 108:1386-1393 (2017). Human . Read more (PubMed: 28474805) »

See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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