Key features and details
- Rabbit polyclonal to ClC-5
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-ClC-5 antibody
See all ClC-5 primary antibodies
DescriptionRabbit polyclonal to ClC-5
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Rat, Rabbit, Guinea pig, Pig
Recombinant fragment corresponding to Human ClC-5 aa 62-363.
VFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIKTITLVLAVSSGLSLG KEGPLVHVACCCGNILCHCFNKYRKNEAKRREVLSAAAAAGVSVAFGAPI GGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSRLVLFYVE FHTPWHLFELVPFILLGIFGGLWGALFIRTNIAWCRKRKTTQLGKYPVIE VLVVTAITAILAFPNEYTRMSTSELISELFNDYGLLDSSKLCDYENRFNT SKGGELPDRPAGVGVYSAMWQLALTLILKIVITIFTFGMKIPSGLFIPSM AV
Database link: NP_000075
- A431 whole cell lysate, HepG2 and Raji lysates.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 10% Glycerol (glycerin, glycerine)
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab97482 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 83 kDa.|
FunctionProton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.
Tissue specificityKidney. Moderately expressed in aortic vascular smooth muscle and endothelial cells, and at a slightly higher level in the coronary vascular smooth muscle.
Involvement in diseaseHypophosphatemic rickets, X-linked recessive
Low molecular weight proteinuria with hypercalciuria and nephrocalcinosis
Sequence similaritiesBelongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
Contains 2 CBS domains.
modificationsUbiquitinated by NEDD4L in the presence of albumin; which promotes endocytosis and proteasomal degradation.
Cellular localizationGolgi apparatus membrane. Endosome membrane. Cell membrane.
- Information by UniProt
- Chloride Channel 5 antibody
- Chloride channel protein 5 antibody
- Chloride channel voltage sensitive 5 antibody
ab97482 has not yet been referenced specifically in any publications.