Product nameAnti-ClC-5 antibody - C-terminal
See all ClC-5 primary antibodies
DescriptionRabbit polyclonal to ClC-5 - C-terminal
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Mouse, Rat, Human
Predicted to work with: Rabbit, Guinea pig, Pig, Orangutan
Recombinant fragment corresponding to Human ClC-5 aa 567-746 (C terminal).
YPFL EAKEEFAHKT LAMDVMKPRR NDPLLTVLTQ DSMTVEDVET IISETTYSGF PVVVSRESQR LVGFVLRRDL IISIENARKK QDGVVSTSII YFTEHSPPLP PYTPPTLKLR NILDLSPFTV TDLTPMEIVV DIFRKLGLRQ CLVTHNGRLL GIITKKDVLK HIAQMANQDP DSILFN
Database link: P51795
- SW480, U937, HepG2, A673, THP1, H460, mouse kidney, mouse ovary and mouse brain extracts.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 49% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab188503 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/2000. Predicted molecular weight: 83 kDa.|
|IHC-P||1/50 - 1/200.|
FunctionProton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.
Tissue specificityKidney. Moderately expressed in aortic vascular smooth muscle and endothelial cells, and at a slightly higher level in the coronary vascular smooth muscle.
Involvement in diseaseHypophosphatemic rickets, X-linked recessive
Low molecular weight proteinuria with hypercalciuria and nephrocalcinosis
Sequence similaritiesBelongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
Contains 2 CBS domains.
modificationsUbiquitinated by NEDD4L in the presence of albumin; which promotes endocytosis and proteasomal degradation.
Cellular localizationGolgi apparatus membrane. Endosome membrane. Cell membrane.
- Information by UniProt
- Chloride Channel 5 antibody
- Chloride channel protein 5 antibody
- Chloride channel voltage sensitive 5 antibody
All lanes : Anti-ClC-5 antibody - C-terminal (ab188503) at 1/500 dilution
Lane 1 : SW480 cell extract
Lane 2 : U937 cell extract
Lane 3 : HepG2 cell extract
Lane 4 : A673 cell extract
Lane 5 : THP1 cell extract
Lane 6 : H460 cell extract
Lane 7 : Mouse kidney extract
Lane 8 : Mouse ovary extract
Lane 9 : Mouse brain extract
Predicted band size: 83 kDa
ab188503 has not yet been referenced specifically in any publications.