Overview

  • Product name

    Anti-ClC-5 antibody - C-terminal
    See all ClC-5 primary antibodies
  • Description

    Rabbit polyclonal to ClC-5 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
    Predicted to work with: Rabbit, Guinea pig, Pig, Orangutan
  • Immunogen

    Recombinant fragment corresponding to Human ClC-5 aa 567-746 (C terminal).
    Sequence:

    YPFL EAKEEFAHKT LAMDVMKPRR NDPLLTVLTQ DSMTVEDVET IISETTYSGF PVVVSRESQR LVGFVLRRDL IISIENARKK QDGVVSTSII YFTEHSPPLP PYTPPTLKLR NILDLSPFTV TDLTPMEIVV DIFRKLGLRQ CLVTHNGRLL GIITKKDVLK HIAQMANQDP DSILFN


    Database link: P51795

  • Positive control

    • SW480, U937, HepG2, A673, THP1, H460, mouse kidney, mouse ovary and mouse brain extracts.

Properties

Applications

Our Abpromise guarantee covers the use of ab188503 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 83 kDa.
IHC-P 1/50 - 1/200.

Target

  • Function

    Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function.
  • Tissue specificity

    Kidney. Moderately expressed in aortic vascular smooth muscle and endothelial cells, and at a slightly higher level in the coronary vascular smooth muscle.
  • Involvement in disease

    Hypophosphatemic rickets, X-linked recessive
    Nephrolithiasis 2
    Nephrolithiasis 1
    Low molecular weight proteinuria with hypercalciuria and nephrocalcinosis
  • Sequence similarities

    Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.
    Contains 2 CBS domains.
  • Post-translational
    modifications

    Ubiquitinated by NEDD4L in the presence of albumin; which promotes endocytosis and proteasomal degradation.
  • Cellular localization

    Golgi apparatus membrane. Endosome membrane. Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Chloride Channel 5 antibody
    • Chloride channel protein 5 antibody
    • Chloride channel voltage sensitive 5 antibody
    • Chloride transporter ClC-5 antibody
    • ClC-5 antibody
    • CLC5 antibody
    • CLCK2 antibody
    • CLCN5 antibody
    • CLCN5_HUMAN antibody
    • DENTS antibody
    • H(+)/Cl(-) exchange transporter 5 antibody
    • hCIC-K2 antibody
    • NPHL1 antibody
    • NPHL2 antibody
    • Voltage gated chloride ion channel CLCN5 antibody
    • XLRH antibody
    • XRN antibody
    see all

Images

  • All lanes : Anti-ClC-5 antibody - C-terminal (ab188503) at 1/500 dilution

    Lane 1 : SW480 cell extract
    Lane 2 : U937 cell extract
    Lane 3 : HepG2 cell extract
    Lane 4 : A673 cell extract
    Lane 5 : THP1 cell extract
    Lane 6 : H460 cell extract
    Lane 7 : Mouse kidney extract
    Lane 8 : Mouse ovary extract
    Lane 9 : Mouse brain extract

    Predicted band size: 83 kDa

References

ab188503 has not yet been referenced specifically in any publications.

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There are currently no Customer reviews or Questions for ab188503.
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