Key features and details
- Rabbit polyclonal to CLCN1 - C-terminal
- Suitable for: WB, IHC-P
- Reacts with: Mouse, Human
- Isotype: IgG
Product nameAnti-CLCN1 antibody - C-terminal
DescriptionRabbit polyclonal to CLCN1 - C-terminal
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Mouse, Human
Recombinant fragment within Human CLCN1 (C terminal). The exact sequence is proprietary.
Database link: P35523
- 293T cell extract and Mouse liver tissue extract
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab189857 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/2000. Predicted molecular weight: 109 kDa.|
|IHC-P||1/50 - 1/200.|
FunctionVoltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
Tissue specificityPredominantly expressed in skeletal muscles.
Involvement in diseaseDefects in CLCN1 are the cause of Thomsen disease (THD) [MIM:160800]; also known as autosomal dominant myotonia congenita (MCD). THD is characterized by skeletal muscle stiffness (delayed relaxation), due to membrane hyperexcitability. A variant form of Thomsen disease is myotonia levior that is characterized by milder symptoms, later onset and absence of muscle hypo- and hypertrophy.
Defects in CLCN1 are the cause of autosomal recessive myotonia congenita (MCR) [MIM:255700]; also known as Becker disease.
Sequence similaritiesBelongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily.
Contains 2 CBS domains.
- Information by UniProt
- Chloride channel protein 1 antibody
- Chloride channel protein antibody
- Chloride channel protein skeletal muscle antibody
ab189857 has been referenced in 1 publication.
- Subramaniam D et al. Suppressing STAT5 signaling affects osteosarcoma growth and stemness. Cell Death Dis 11:149 (2020). PubMed: 32094348