Overview

  • Product name

    Anti-CLCN1 antibody - C-terminal
  • Description

    Rabbit polyclonal to CLCN1 - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment within Human CLCN1 (C terminal). The exact sequence is proprietary.
    Database link: P35523

  • Positive control

    • 293T cell extract and Mouse liver tissue extract

Properties

Applications

Our Abpromise guarantee covers the use of ab189857 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 109 kDa.
IHC-P 1/50 - 1/200.

Target

  • Function

    Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport.
  • Tissue specificity

    Predominantly expressed in skeletal muscles.
  • Involvement in disease

    Defects in CLCN1 are the cause of Thomsen disease (THD) [MIM:160800]; also known as autosomal dominant myotonia congenita (MCD). THD is characterized by skeletal muscle stiffness (delayed relaxation), due to membrane hyperexcitability. A variant form of Thomsen disease is myotonia levior that is characterized by milder symptoms, later onset and absence of muscle hypo- and hypertrophy.
    Defects in CLCN1 are the cause of autosomal recessive myotonia congenita (MCR) [MIM:255700]; also known as Becker disease.
  • Sequence similarities

    Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily.
    Contains 2 CBS domains.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Chloride channel protein 1 antibody
    • Chloride channel protein antibody
    • Chloride channel protein skeletal muscle antibody
    • CIC 1 antibody
    • CIC1 antibody
    • ClC-1 antibody
    • CLC1 antibody
    • Clcn1 antibody
    • CLCN1_HUMAN antibody
    • MGC138361 antibody
    • MGC142055 antibody
    • skeletal muscle antibody
    see all

Images

  • All lanes : Anti-CLCN1 antibody - C-terminal (ab189857) at 1/500 dilution

    Lane 1 : 293T cell extract
    Lane 2 : Mouse liver tissue extract

    Predicted band size: 109 kDa

References

ab189857 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab189857.
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