• Product name

    Anti-CLCNKB antibody [EPR8414(2)]
    See all CLCNKB primary antibodies
  • Description

    Rabbit monoclonal [EPR8414(2)] to CLCNKB
  • Host species

  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: Flow Cyt,ICC/IF,IHC-P or IP
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human CLCNKB (N terminal). The exact sequence is proprietary.

  • Positive control

    • Human fetal lung, HepG2, A673 and Human fetal kidney cell lysates.
  • General notes

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.


    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab167158 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 75 kDa.
  • Application notes
    Is unsuitable for Flow Cyt,ICC/IF,IHC-P or IP.
  • Target

    • Function

      Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms.
    • Tissue specificity

      Expressed predominantly in the kidney.
    • Involvement in disease

      Defects in CLCNKB are the cause of Bartter syndrome type 3 (BS3) [MIM:607364]; also known as classic Bartter syndrome. It is an autosomal recessive form of often severe intravascular volume depletion due to renal salt-wasting associated with low blood pressure, hypokalemic alkalosis, hypercalciuria, and normal serum magnesium levels.
      Defects in CLCNKB are a cause of Bartter syndrome type 4B (BS4B) [MIM:613090]. A digenic, recessive disorder characterized by impaired salt reabsorption in the thick ascending loop of Henle with pronounced salt wasting, hypokalemic metabolic alkalosis, and varying degrees of hypercalciuria. Bartter syndrome type 4B is associated with sensorineural deafness.
    • Sequence similarities

      Belongs to the chloride channel (TC 2.A.49) family. CLCNKB subfamily.
      Contains 2 CBS domains.
    • Cellular localization

      Cell membrane.
    • Information by UniProt
    • Database links

    • Alternative names

      • Bartter syndrome type 3 antibody
      • Chloride channel Kb antibody
      • Chloride channel kidney B antibody
      • Chloride channel protein ClC-Kb antibody
      • Chloride channel voltage sensitive Kb antibody
      • ClC K2 antibody
      • ClC-K2 antibody
      • ClCK2 antibody
      • CLCKB antibody
      • CLCKB_HUMAN antibody
      • CLCNKB antibody
      • hClC Kb antibody
      • hClCKb antibody
      • MGC24087 antibody
      • OTTHUMP00000011120 antibody
      • OTTHUMP00000011121 antibody
      • RP11 5P18.8 antibody
      see all


    • All lanes : Anti-CLCNKB antibody [EPR8414(2)] (ab167158) at 1/1000 dilution

      Lane 1 : Human fetal lung cell lysate
      Lane 2 : HepG2 cell lysate
      Lane 3 : A673 cell lysate
      Lane 4 : Human fetal kidney cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 75 kDa


    ab167158 has not yet been referenced specifically in any publications.

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