- References (1)
Product nameCldU (5-chloro-2'-deoxyuridine), Halogenated uridine derivative
DescriptionHalogenated uridine derivative
Thymidine analogue, readily incorporated following phosphorylation, into newly synthesized DNA in place of thymidine. Used to study the miscoding potential of hypochlorous acid damage to DNA and DNA precursors.
Storage instructionsStore at -20°C.
Soluble in water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Tuttle AH et al. Immunofluorescent detection of two thymidine analogues (CldU and IdU) in primary tissue. J Vis Exp N/A:N/A (2010). Read more (PubMed: 21178965) »
- Kim CH et al. Polymerase incorporation and miscoding properties of 5-chlorouracil. Chem Res Toxicol 23:740-8 (2010). Read more (PubMed: 20104909) »
- Yamada K et al. Discrimination of cell nuclei in early S-phase, mid-to-late S-phase, and G(2)/M-phase by sequential administration of 5-bromo-2'-deoxyuridine and 5-chloro-2'-deoxyuridine. J Histochem Cytochem 53:1365-70 (2005). Read more (PubMed: 15956030) »
- Heartlein MW et al. SCE induction is proportional to substitution in DNA for thymidine by CldU and BrdU. Mutat Res 107:103-9 (1983). Read more (PubMed: 6828032) »