CldU (5-chloro-2'-deoxyuridine), Halogenated uridine derivative (ab213715)

Overview

  • Product name

    CldU (5-chloro-2'-deoxyuridine), Halogenated uridine derivative
  • Description

    Halogenated uridine derivative
  • Alternative names

    • 2’-Deoxy-5-chlorouridine
    • 5-Chlorodeoxyuridine
    • 5-CldU
    • Chlorodeoxyuridine
  • Biological description

    Thymidine analogue, readily incorporated following phosphorylation, into newly synthesized DNA in place of thymidine. Used to study the miscoding potential of hypochlorous acid damage to DNA and DNA precursors.

  • CAS Number

    50-90-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-Chloro-2'-deoxyuridine

  • Molecular weight

    262.65
  • Molecular formula

    C9H11ClN2O5
  • PubChem identifier

    65510
  • Storage instructions

    Store at -20°C.
  • Solubility overview

    Soluble in water

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1[C@@H]([C@H](O[C@H]1N2C=C(C(=O)NC2=O)Cl)CO)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Tuttle AH  et al. Immunofluorescent detection of two thymidine analogues (CldU and IdU) in primary tissue. J Vis Exp N/A:N/A (2010). Read more (PubMed: 21178965) »
  • Kim CH  et al. Polymerase incorporation and miscoding properties of 5-chlorouracil. Chem Res Toxicol 23:740-8 (2010). Read more (PubMed: 20104909) »
  • Yamada K  et al. Discrimination of cell nuclei in early S-phase, mid-to-late S-phase, and G(2)/M-phase by sequential administration of 5-bromo-2'-deoxyuridine and 5-chloro-2'-deoxyuridine. J Histochem Cytochem 53:1365-70 (2005). Read more (PubMed: 15956030) »
  • Heartlein MW  et al. SCE induction is proportional to substitution in DNA for thymidine by CldU and BrdU. Mutat Res 107:103-9 (1983). Read more (PubMed: 6828032) »
See 1 Publication for this product

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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