Validated using a knockout cell line

Anti-Cleaved PARP1 antibody [E51] (ab32064)

Publishing research using ab32064? Please let us know so that we can cite the reference in this datasheet.

ab32064 has been referenced in 70 publications.

  • Bhowmick S  et al. Neurodegeneration and Sensorimotor Deficits in the Mouse Model of Traumatic Brain Injury. Brain Sci 8:N/A (2018). PubMed: 29316623
  • Ismael S  et al. Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke. Sci Rep 8:5971 (2018). PubMed: 29654318
  • Yu X  et al. d-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer. Onco Targets Ther 11:1833-1847 (2018). PubMed: 29670359
  • Pan L  et al. miR-125a induces apoptosis, metabolism disorder and migrationimpairment in pancreatic cancer cells by targeting Mfn2-related mitochondrial fission. Int J Oncol 53:124-136 (2018). PubMed: 29749475
  • Shukla R  et al. Antioxidant and Antiapoptotic effect of aqueous extract of Pueraria tuberosa (Roxb. Ex Willd.) DC. On streptozotocin-induced diabetic nephropathy in rats. BMC Complement Altern Med 18:156 (2018). PubMed: 29751837
  • Luo Y  et al. Exogenous hydrogen sulfide ameliorates high glucose-induced myocardial injury & inflammation via the CIRP-MAPK signaling pathway in H9c2 cardiac cells. Life Sci N/A:N/A (2018). WB . PubMed: 29857073
  • Xu W  et al. Knockdown of HuR represses osteosarcoma cells migration, invasion and stemness through inhibition of YAP activation and increases susceptibility to chemotherapeutic agents. Biomed Pharmacother 102:587-593 (2018). WB . PubMed: 29597092
  • Yang J  et al. Honokiol suppresses proliferation and induces apoptosis via regulation of the miR-21/PTEN/PI3K/AKT signaling pathway in human osteosarcoma cells. Int J Mol Med 41:1845-1854 (2018). PubMed: 29393336
  • Zhang K  et al. PU.1/microRNA-142-3p targets ATG5/ATG16L1 to inactivate autophagy and sensitize hepatocellular carcinoma cells to sorafenib. Cell Death Dis 9:312 (2018). PubMed: 29472524
  • Liu W  et al. Dioscin inhibits stem-cell-like properties and tumor growth of osteosarcoma through Akt/GSK3/ß-catenin signaling pathway. Cell Death Dis 9:343 (2018). PubMed: 29497056
  • Azad T  et al. A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis. Nat Commun 9:1061 (2018). WB . PubMed: 29535383
  • Shen W  et al. Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins. Nucleic Acids Res 46:2204-2217 (2018). PubMed: 29390093
  • Kolluri KK  et al. Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells. Elife 7:N/A (2018). PubMed: 29345617
  • Lyon CA  et al. Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression. Sci Rep 7:17342 (2017). IHC-P ; Mouse . PubMed: 29229950
  • Li X  et al. Prolonged exposure to extracellular lumican restrains pancreatic adenocarcinoma growth. Oncogene 36:5432-5438 (2017). WB . PubMed: 28534517
  • Waller KA  et al. Friction-Induced Mitochondrial Dysregulation Contributes to Joint Deterioration in Prg4 Knockout Mice. Int J Mol Sci 18:N/A (2017). WB . PubMed: 28604608
  • Aung LHH  et al. Knockdown of Mtfp1 can minimize doxorubicin cardiotoxicity by inhibiting Dnm1l-mediated mitochondrial fission. J Cell Mol Med 21:3394-3404 (2017). WB . PubMed: 28643438
  • Yi FT & Lu QP Mucin 1 promotes radioresistance in hepatocellular carcinoma cells through activation of JAK2/STAT3 signaling. Oncol Lett 14:7571-7576 (2017). PubMed: 29344203
  • Yu D  et al. RNA-binding protein HuR promotes bladder cancer progression by competitively binding to the long noncoding HOTAIR with miR-1. Onco Targets Ther 10:2609-2619 (2017). PubMed: 28553126
  • Fan L  et al. Pekinenin E Inhibits the Growth of Hepatocellular Carcinoma by Promoting Endoplasmic Reticulum Stress Mediated Cell Death. Front Pharmacol 8:424 (2017). PubMed: 28706487
  • Lin MX  et al. Lobocrassin B Induces Apoptosis of Human Lung Cancer and Inhibits Tumor Xenograft Growth. Mar Drugs 15:N/A (2017). PubMed: 29207557
  • Wang C  et al. Krüppel-like factor 2 suppresses human gastric tumorigenesis through inhibiting PTEN/AKT signaling. Oncotarget 8:100358-100370 (2017). PubMed: 29245984
  • Kitagawa M  et al. Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality. Nat Commun 8:2200 (2017). PubMed: 29259156
  • Aung LHH  et al. Mitochondrial protein 18 (MTP18) plays a pro-apoptotic role in chemotherapy-induced gastric cancer cell apoptosis. Oncotarget 8:56582-56597 (2017). WB . PubMed: 28915614
  • Liu W  et al. Protective effect of ulinastatin on severe pulmonary infection under immunosuppression and its molecular mechanism. Exp Ther Med 14:3583-3588 (2017). PubMed: 29042952
  • He T  et al. Long non-coding RNA CASC15 is upregulated in hepatocellular carcinoma and facilitates hepatocarcinogenesis. Int J Oncol 51:1722-1730 (2017). PubMed: 29075788
  • Kollareddy M  et al. The small molecule inhibitor YK-4-279 disrupts mitotic progression of neuroblastoma cells, overcomes drug resistance and synergizes with inhibitors of mitosis. Cancer Lett 403:74-85 (2017). PubMed: 28602975
  • Szobi A  et al. Analysis of necroptotic proteins in failing human hearts. J Transl Med 15:86 (2017). WB ; Human . PubMed: 28454582
  • Özata DM  et al. Loss of miR-514a-3p regulation of PEG3 activates the NF-kappa B pathway in human testicular germ cell tumors. Cell Death Dis 8:e2759 (2017). WB ; Human . PubMed: 28471449
  • Gao MQ  et al. Hispidulin suppresses tumor growth and metastasis in renal cell carcinoma by modulating ceramide-sphingosine 1-phosphate rheostat. Am J Cancer Res 7:1501-1514 (2017). WB ; Human . PubMed: 28744400
  • Liu J  et al. miR-223-3p regulates cell growth and apoptosis via FBXW7 suggesting an oncogenic role in human testicular germ cell tumors. Int J Oncol 50:356-364 (2017). WB . PubMed: 28000896
  • Wang L  et al. An In Vivo Pharmacological Screen Identifies Cholinergic Signaling as a Therapeutic Target in Glial-Based Nervous System Disease. J Neurosci 36:1445-55 (2016). PubMed: 26843629
  • Bonneau B  et al. IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact. Elife 5:N/A (2016). PubMed: 27995898
  • Qin Q  et al. miR-134 inhibits non-small cell lung cancer growth by targeting the epidermal growth factor receptor. J Cell Mol Med N/A:N/A (2016). IHC . PubMed: 27241841
  • Song J  et al. Cordyceps militaris induces tumor cell death via the caspase-dependent mitochondrial pathway in HepG2 and MCF-7 cells. Mol Med Rep 13:5132-40 (2016). WB ; Human . PubMed: 27109250
  • Zeng W  et al. Silencing of hERG1 Gene Inhibits Proliferation and Invasion, and Induces Apoptosis in Human Osteosarcoma Cells by Targeting the NF-?B Pathway. J Cancer 7:746-57 (2016). WB ; Human . PubMed: 27076857
  • Shao X  et al. Induction of Autophagy and Apoptosis via PI3K/AKT/TOR Pathways by Azadirachtin A in Spodoptera litura Cells. Sci Rep 6:35482 (2016). PubMed: 27752103
  • Xue H  et al. A Novel Tumor-promoting Mechanism of IL6 and the Therapeutic Efficacy of Tocilizumab: Hypoxia-induced IL6 Is a Potent Autophagy Initiator in Glioblastoma via the p-STAT3-MIR155-3p-CREBRF Pathway. Autophagy N/A:0 (2016). WB ; Human . PubMed: 27163161
  • Wang Y  et al. Tricholoma matsutake Aqueous Extract Induces Hepatocellular Carcinoma Cell Apoptosis via Caspase-Dependent Mitochondrial Pathway. Biomed Res Int 2016:9014364 (2016). WB . PubMed: 28018916
  • Yan Y  et al. Ras-related associated with diabetes gene acts as a suppressor and inhibits Warburg effect in hepatocellular carcinoma. Onco Targets Ther 9:3925-37 (2016). IHC . PubMed: 27418837
  • Ganz M  et al. Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat-cholesterol-sugar diet model in mice. J Transl Med 13:193 (2015). PubMed: 26077675
  • Sanchez-Niño MD  et al. Albumin-induced apoptosis of tubular cells is modulated by BASP1. Cell Death Dis 6:e1644 (2015). WB ; Human . PubMed: 25675304
  • Skrzypek K  et al. Constitutive activation of MET signaling impairs myogenic differentiation of rhabdomyosarcoma and promotes its development and progression. Oncotarget 6:31378-98 (2015). IHC-P . PubMed: 26384300
  • Zhang P  et al. Antitumor effects of pharmacological EZH2 inhibition on malignant peripheral nerve sheath tumor through the miR-30a and KPNB1 pathway. Mol Cancer 14:55 (2015). PubMed: 25890085
  • Chopra M  et al. Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD. Blood 126:437-44 (2015). PubMed: 26012567
  • Tahiri A  et al. Deregulation of cancer-related miRNAs is a common event in both benign and malignant human breast tumors. Carcinogenesis 35:76-85 (2014). ICC/IF ; Human . PubMed: 24104550
  • Tarín C  et al. Tumor necrosis factor-like weak inducer of apoptosis or Fn14 deficiency reduce elastase perfusion-induced aortic abdominal aneurysm in mice. J Am Heart Assoc 3:N/A (2014). PubMed: 25092786
  • Van Looy T  et al. Characterization and assessment of the sensitivity and resistance of a newly established human gastrointestinal stromal tumour xenograft model to treatment with tyrosine kinase inhibitors. Clin Sarcoma Res 4:10 (2014). IHC-P ; Human . PubMed: 25132955
  • Steffensen MA  et al. Suppressors of cytokine signaling 1 and 3 are upregulated in brain resident cells in response to virus-induced inflammation of the central nervous system via at least two distinctive pathways. J Virol 88:14090-104 (2014). IHC (PFA fixed) ; Mouse . PubMed: 25253351
  • Urbanik T  et al. CYLD deletion triggers nuclear factor-?B-signaling and increases cell death resistance in murine hepatocytes. World J Gastroenterol 20:17049-64 (2014). IHC-P ; Mouse . PubMed: 25493017
  • Zhang P  et al. EZH2-miR-30d-KPNB1 pathway regulates malignant peripheral nerve sheath tumour cell survival and tumourigenesis. J Pathol 232:308-18 (2014). PubMed: 24132643
  • Hongisto V  et al. The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells - A data description. Genom Data 2:249-53 (2014). PubMed: 26484103
  • Hegde VR  et al. Glia are critical for the neuropathology of complex I deficiency in Drosophila. Hum Mol Genet 23:4686-92 (2014). PubMed: 24760769
  • Aure MR  et al. Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors. Genome Biol 14:R126 (2013). PubMed: 24257477
  • Pachel C  et al. Exogenous Administration of a Recombinant Variant of TWEAK Impairs Healing after Myocardial Infarction by Aggravation of Inflammation. PLoS One 8:e78938 (2013). IHC-P ; Mouse . PubMed: 24244389
  • Sharifi R  et al. Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease. EMBO J 32:1225-37 (2013). PubMed: 23481255
  • Sánchez-Alvarez R  et al. Ethanol diverts early neuronal differentiation trajectory of embryonic stem cells by disrupting the balance of lineage specifiers. PLoS One 8:e63794 (2013). Mouse . PubMed: 23724002
  • Melis MH  et al. Sustained tumour eradication after induced caspase-3 activation and synchronous tumour apoptosis requires an intact host immune response. Cell Death Differ 20:765-73 (2013). Mouse . PubMed: 23412345
  • Brunetto E  et al. CDC25A protein stability represents a previously unrecognized target of HER2 signaling in human breast cancer: implication for a potential clinical relevance in trastuzumab treatment. Neoplasia 15:579-90 (2013). WB . PubMed: 23730206
  • Leivonen SK  et al. High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth. Mol Oncol N/A:N/A (2013). Human . PubMed: 24148764
  • Sahlberg KK  et al. The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells. Mol Oncol 7:392-401 (2013). PubMed: 23253899
  • Betton B  et al. Influence of pH on the Cytotoxic Activity of Inositol Hexakisphosphate (IP6) in Prostate Cancer. Front Oncol 1:40 (2011). PubMed: 22655245
  • Mitra M  et al. Enhanced in vitro antiproliferative effects of EpCAM antibody-functionalized paclitaxel-loaded PLGA nanoparticles in retinoblastoma cells. Mol Vis 17:2724-37 (2011). Flow Cyt ; Human . PubMed: 22065926
  • Mitra M  et al. Reversal of stathmin-mediated microtubule destabilization sensitizes retinoblastoma cells to a low dose of antimicrotubule agents: a novel synergistic therapeutic intervention. Invest Ophthalmol Vis Sci 52:5441-8 (2011). PubMed: 21546534
  • Demers M  et al. Overexpression of galectin-7, a myoepithelial cell marker, enhances spontaneous metastasis of breast cancer cells. Am J Pathol 176:3023-31 (2010). PubMed: 20382700
  • Rodrigues P  et al. Multiple mechanisms of germ cell loss in the perinatal mouse ovary. Reproduction 137:709-20 (2009). PubMed: 19176312
  • Iljin K  et al. High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. Clin Cancer Res 15:6070-8 (2009). WB ; Human . PubMed: 19789329
  • Bai Y  et al. An Ang1-Tie2-PI3K axis in neural progenitor cells initiates survival responses against oxygen and glucose deprivation. Neuroscience 160:371-81 (2009). PubMed: 19409199
  • Dittmer A  et al. Human mesenchymal stem cells induce E-cadherin degradation in breast carcinoma spheroids by activating ADAM10. Cell Mol Life Sci 66:3053-65 (2009). PubMed: 19603142
  • Simonsson M  et al. Low-dose hypersensitive gammaH2AX response and infrequent apoptosis in epidermis from radiotherapy patients. Radiother Oncol 88:388-97 (2008). PubMed: 18524402


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