Validated using a knockout cell line
Recombinant
RabMAb

Recombinant Anti-Cleaved PARP1 antibody [E51] (ab32064)

Knockout Tested Rabbit recombinant monoclonal Cleaved PARP1 antibody [E51]. Validated in WB, IHC and tested in Mouse, Rat, Human. Cited in 95 publication(s). Independently reviewed in 11 review(s).

Publishing research using ab32064? Please let us know so that we can cite the reference in this datasheet.

ab32064 has been referenced in 104 publications.

  • Yang X  et al. Dihomo-?-linolenic acid inhibits growth of xenograft tumors in mice bearing human pancreatic cancer cells (BxPC-3) transfected with delta-5-desaturase shRNA. Redox Biol 20:236-246 (2019). PubMed: 30384258
  • Chen L  et al. Everolimus Reverses Palbociclib Resistance in ER+ Human Breast Cancer Cells by Inhibiting Phosphatidylinositol 3-Kinase(PI3K)/Akt/Mammalian Target of Rapamycin (mTOR) Pathway. Med Sci Monit 25:77-86 (2019). PubMed: 30605443
  • Koike K  et al. Subcutaneous administration of neutralizing antibodies to endothelial monocyte-activating protein II attenuates cigarette smoke-induced lung injury in mice. Am J Physiol Lung Cell Mol Physiol 316:L558-L566 (2019). PubMed: 30628489
  • Qin N  et al. Deubiquitinating enzyme 4 facilitates chemoresistance in glioblastoma by inhibiting P53 activity. Oncol Lett 17:958-964 (2019). PubMed: 30655854
  • Zhou L  et al. Brefeldin A inhibits colorectal cancer growth by triggering Bip/Akt-regulated autophagy. FASEB J 33:5520-5534 (2019). PubMed: 30668917
  • Niu N  et al. Effects of nuclear respiratory factor-1 on apoptosis and mitochondrial dysfunction induced by cobalt chloride in H9C2 cells. Mol Med Rep 19:2153-2163 (2019). PubMed: 30628711
  • Jiang R  et al. Kaempferol protects chondrogenic ATDC5 cells against inflammatory injury triggered by lipopolysaccharide through down-regulating miR-146a. Int Immunopharmacol 69:373-381 (2019). PubMed: 30776646
  • Ouyang H  et al. Mst1-Hippo pathway triggers breast cancer apoptosis via inducing mitochondrial fragmentation in a manner dependent on JNK-Drp1 axis. Onco Targets Ther 12:1147-1159 (2019). PubMed: 30809096
  • Hou Y  et al. Genetic ablation of TAZ induces HepG2 liver cancer cell apoptosis through activating the CaMKII/MIEF1 signaling pathway. Onco Targets Ther 12:1765-1779 (2019). PubMed: 30881030
  • Zhao W  et al. Long noncoding RNA NSCLCAT1 increases non-small cell lung cancer cell invasion and migration through the Hippo signaling pathway by interacting with CDH1. FASEB J 33:1151-1166 (2019). PubMed: 30148675
  • Liu J  et al. Sirtuin-1 protects hair follicle stem cells from TNFa-mediated inflammatory stress via activating the MAPK-ERK-Mfn2 pathway. Life Sci 212:213-224 (2018). PubMed: 30292830
  • Cui X  et al. Ring finger protein 152 inhibits colorectal cancer cell growth and is a novel prognostic biomarker. Am J Transl Res 10:3701-3712 (2018). PubMed: 30662620
  • Hirota T  et al. SETDB1 Links the Meiotic DNA Damage Response to Sex Chromosome Silencing in Mice. Dev Cell 47:645-659.e6 (2018). PubMed: 30393076
  • Kumar S  et al. MiR-375 Regulation of LDHB Plays Distinct Roles in Polyomavirus-Positive and -Negative Merkel Cell Carcinoma. Cancers (Basel) 10:N/A (2018). PubMed: 30441870
  • Zhou L  et al. USP15 inhibits multiple myeloma cell apoptosis through activating a feedback loop with the transcription factor NF-?Bp65. Exp Mol Med 50:151 (2018). PubMed: 30459344
  • Xu Y  et al. Dihomo-?-linolenic acid inhibits xenograft tumor growth in mice bearing shRNA-transfected HCA-7 cells targeting delta-5-desaturase. BMC Cancer 18:1268 (2018). PubMed: 30567534
  • Zhang N  et al. Goserelin promotes the apoptosis of epithelial ovarian cancer cells by upregulating forkhead box O1 through the PI3K/AKT signaling pathway. Oncol Rep 39:1034-1042 (2018). PubMed: 29286125
  • Pan BL  et al. Effects of MicroRNA-206 on Osteosarcoma Cell Proliferation, Apoptosis, Migration and Invasion by Targeting ANXA2 Through the AKT Signaling Pathway. Cell Physiol Biochem 45:1410-1422 (2018). PubMed: 29462818
  • Jin X  et al. Overexpression of retinoblastoma-binding protein 4 contributes to the radiosensitivity of AGS gastric cancer cells via phosphoinositide3-kinase/protein kinase B pathway suppression. Mol Med Rep 18:1571-1581 (2018). PubMed: 29901205
  • Yang J  et al. Honokiol suppresses proliferation and induces apoptosis via regulation of the miR-21/PTEN/PI3K/AKT signaling pathway in human osteosarcoma cells. Int J Mol Med 41:1845-1854 (2018). PubMed: 29393336
  • Zhang K  et al. PU.1/microRNA-142-3p targets ATG5/ATG16L1 to inactivate autophagy and sensitize hepatocellular carcinoma cells to sorafenib. Cell Death Dis 9:312 (2018). PubMed: 29472524
  • Liu W  et al. Dioscin inhibits stem-cell-like properties and tumor growth of osteosarcoma through Akt/GSK3/ß-catenin signaling pathway. Cell Death Dis 9:343 (2018). PubMed: 29497056
  • Azad T  et al. A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis. Nat Commun 9:1061 (2018). WB . PubMed: 29535383
  • Shen W  et al. Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS proteins. Nucleic Acids Res 46:2204-2217 (2018). PubMed: 29390093
  • Kolluri KK  et al. Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells. Elife 7:N/A (2018). PubMed: 29345617
  • Bhowmick S  et al. Neurodegeneration and Sensorimotor Deficits in the Mouse Model of Traumatic Brain Injury. Brain Sci 8:N/A (2018). PubMed: 29316623
  • Ismael S  et al. Inhibition of the NLRP3-inflammasome as a potential approach for neuroprotection after stroke. Sci Rep 8:5971 (2018). PubMed: 29654318
  • Yu X  et al. d-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer. Onco Targets Ther 11:1833-1847 (2018). PubMed: 29670359
  • Pan L  et al. miR-125a induces apoptosis, metabolism disorder and migrationimpairment in pancreatic cancer cells by targeting Mfn2-related mitochondrial fission. Int J Oncol 53:124-136 (2018). PubMed: 29749475
  • Shukla R  et al. Antioxidant and Antiapoptotic effect of aqueous extract of Pueraria tuberosa (Roxb. Ex Willd.) DC. On streptozotocin-induced diabetic nephropathy in rats. BMC Complement Altern Med 18:156 (2018). PubMed: 29751837
  • Luo Y  et al. Exogenous hydrogen sulfide ameliorates high glucose-induced myocardial injury & inflammation via the CIRP-MAPK signaling pathway in H9c2 cardiac cells. Life Sci N/A:N/A (2018). WB . PubMed: 29857073
  • Xu W  et al. Knockdown of HuR represses osteosarcoma cells migration, invasion and stemness through inhibition of YAP activation and increases susceptibility to chemotherapeutic agents. Biomed Pharmacother 102:587-593 (2018). WB . PubMed: 29597092
  • Kaymak A  et al. Role for the transcriptional activator ZRF1 in early metastatic events in breast cancer progression and endocrine resistance. Oncotarget 9:28666-28690 (2018). PubMed: 29983888
  • Zheng Y  et al. Pinocembrin induces ER stress mediated apoptosis and suppresses autophagy in melanoma cells. Cancer Lett 431:31-42 (2018). PubMed: 29807112
  • Ding H & Wen Z Overexpression of C-sis inhibits H2O2-induced Buffalo rat liver cell apoptosis in vitro and alleviates liver injury in a rat model of fulminant hepatic failure. Int J Mol Med 42:873-882 (2018). PubMed: 29786113
  • See CS  et al. Discovery of the cancer cell selective dual acting anti-cancer agent (Z)-2-(1H-indol-3-yl)-3-(isoquinolin-5-yl)acrylonitrile (A131). Eur J Med Chem 156:344-367 (2018). PubMed: 30015072
  • Cao L  et al. Pseudo-phosphorylation at AT8 epitopes regulates the tau truncation at aspartate 421. Exp Cell Res 370:103-115 (2018). PubMed: 29908160
  • Zhang H  et al. USP22 promotes resistance to EGFR-TKIs by preventing ubiquitination-mediated EGFR degradation in EGFR-mutant lung adenocarcinoma. Cancer Lett 433:186-198 (2018). PubMed: 29981430
  • Liu L  et al. Silencing of PINK1 represses cell growth, migration and induces apoptosis of lung cancer cells. Biomed Pharmacother 106:333-341 (2018). PubMed: 29966978
  • Qin J  et al. Tanshinone IIA inhibits cervix carcinoma stem cells migration and invasion via inhibiting YAP transcriptional activity. Biomed Pharmacother 105:758-765 (2018). PubMed: 29909343
  • Waller KA  et al. Friction-Induced Mitochondrial Dysregulation Contributes to Joint Deterioration in Prg4 Knockout Mice. Int J Mol Sci 18:N/A (2017). WB . PubMed: 28604608
  • Aung LHH  et al. Knockdown of Mtfp1 can minimize doxorubicin cardiotoxicity by inhibiting Dnm1l-mediated mitochondrial fission. J Cell Mol Med 21:3394-3404 (2017). WB . PubMed: 28643438
  • Yi FT & Lu QP Mucin 1 promotes radioresistance in hepatocellular carcinoma cells through activation of JAK2/STAT3 signaling. Oncol Lett 14:7571-7576 (2017). PubMed: 29344203
  • Yu D  et al. RNA-binding protein HuR promotes bladder cancer progression by competitively binding to the long noncoding HOTAIR with miR-1. Onco Targets Ther 10:2609-2619 (2017). PubMed: 28553126
  • Fan L  et al. Pekinenin E Inhibits the Growth of Hepatocellular Carcinoma by Promoting Endoplasmic Reticulum Stress Mediated Cell Death. Front Pharmacol 8:424 (2017). PubMed: 28706487
  • Lin MX  et al. Lobocrassin B Induces Apoptosis of Human Lung Cancer and Inhibits Tumor Xenograft Growth. Mar Drugs 15:N/A (2017). PubMed: 29207557
  • Wang C  et al. Krüppel-like factor 2 suppresses human gastric tumorigenesis through inhibiting PTEN/AKT signaling. Oncotarget 8:100358-100370 (2017). PubMed: 29245984
  • Kitagawa M  et al. Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality. Nat Commun 8:2200 (2017). PubMed: 29259156
  • Aung LHH  et al. Mitochondrial protein 18 (MTP18) plays a pro-apoptotic role in chemotherapy-induced gastric cancer cell apoptosis. Oncotarget 8:56582-56597 (2017). WB . PubMed: 28915614
  • Liu W  et al. Protective effect of ulinastatin on severe pulmonary infection under immunosuppression and its molecular mechanism. Exp Ther Med 14:3583-3588 (2017). PubMed: 29042952
  • He T  et al. Long non-coding RNA CASC15 is upregulated in hepatocellular carcinoma and facilitates hepatocarcinogenesis. Int J Oncol 51:1722-1730 (2017). PubMed: 29075788
  • Kollareddy M  et al. The small molecule inhibitor YK-4-279 disrupts mitotic progression of neuroblastoma cells, overcomes drug resistance and synergizes with inhibitors of mitosis. Cancer Lett 403:74-85 (2017). PubMed: 28602975
  • Szobi A  et al. Analysis of necroptotic proteins in failing human hearts. J Transl Med 15:86 (2017). WB ; Human . PubMed: 28454582
  • Özata DM  et al. Loss of miR-514a-3p regulation of PEG3 activates the NF-kappa B pathway in human testicular germ cell tumors. Cell Death Dis 8:e2759 (2017). WB ; Human . PubMed: 28471449
  • Gao MQ  et al. Hispidulin suppresses tumor growth and metastasis in renal cell carcinoma by modulating ceramide-sphingosine 1-phosphate rheostat. Am J Cancer Res 7:1501-1514 (2017). WB ; Human . PubMed: 28744400
  • Liu J  et al. miR-223-3p regulates cell growth and apoptosis via FBXW7 suggesting an oncogenic role in human testicular germ cell tumors. Int J Oncol 50:356-364 (2017). WB . PubMed: 28000896
  • Lyon CA  et al. Aneurysm Severity is Increased by Combined Mmp-7 Deletion and N-cadherin Mimetic (EC4-Fc) Over-Expression. Sci Rep 7:17342 (2017). IHC-P ; Mouse . PubMed: 29229950
  • Li X  et al. Prolonged exposure to extracellular lumican restrains pancreatic adenocarcinoma growth. Oncogene 36:5432-5438 (2017). WB . PubMed: 28534517
  • Zheng S  et al. Inhibiting p53 Acetylation Reduces Cancer Chemotoxicity. Cancer Res 77:4342-4354 (2017). PubMed: 28655792
  • Zhao Z  et al. Rosiglitazone Exerts an Anti-depressive Effect in Unpredictable Chronic Mild-Stress-Induced Depressive Mice by Maintaining Essential Neuron Autophagy and Inhibiting Excessive Astrocytic Apoptosis. Front Mol Neurosci 10:293 (2017). PubMed: 28959186
  • Chen L  et al. Juglanin inhibits lung cancer by regulation of apoptosis, ROS and autophagy induction. Oncotarget 8:93878-93898 (2017). PubMed: 29212196
  • Aakula A  et al. Systematic Identification of MicroRNAs That Impact on Proliferation of Prostate Cancer Cells and Display Changed Expression in Tumor Tissue. Eur Urol 69:1120-8 (2016). PubMed: 26489476
  • Tornin J  et al. Inhibition of SP1 by the mithramycin analog EC-8042 efficiently targets tumor initiating cells in sarcoma. Oncotarget 7:30935-50 (2016). PubMed: 27105533
  • Santos JC  et al. SOX9 Elevation Acts with Canonical WNT Signaling to Drive Gastric Cancer Progression. Cancer Res 76:6735-6746 (2016). PubMed: 27569216
  • Wang L  et al. An In Vivo Pharmacological Screen Identifies Cholinergic Signaling as a Therapeutic Target in Glial-Based Nervous System Disease. J Neurosci 36:1445-55 (2016). PubMed: 26843629
  • Bonneau B  et al. IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact. Elife 5:N/A (2016). PubMed: 27995898
  • Qin Q  et al. miR-134 inhibits non-small cell lung cancer growth by targeting the epidermal growth factor receptor. J Cell Mol Med N/A:N/A (2016). IHC . PubMed: 27241841
  • Song J  et al. Cordyceps militaris induces tumor cell death via the caspase-dependent mitochondrial pathway in HepG2 and MCF-7 cells. Mol Med Rep 13:5132-40 (2016). WB ; Human . PubMed: 27109250
  • Zeng W  et al. Silencing of hERG1 Gene Inhibits Proliferation and Invasion, and Induces Apoptosis in Human Osteosarcoma Cells by Targeting the NF-?B Pathway. J Cancer 7:746-57 (2016). WB ; Human . PubMed: 27076857
  • Shao X  et al. Induction of Autophagy and Apoptosis via PI3K/AKT/TOR Pathways by Azadirachtin A in Spodoptera litura Cells. Sci Rep 6:35482 (2016). PubMed: 27752103
  • Xue H  et al. A Novel Tumor-promoting Mechanism of IL6 and the Therapeutic Efficacy of Tocilizumab: Hypoxia-induced IL6 Is a Potent Autophagy Initiator in Glioblastoma via the p-STAT3-MIR155-3p-CREBRF Pathway. Autophagy N/A:0 (2016). WB ; Human . PubMed: 27163161
  • Wang Y  et al. Tricholoma matsutake Aqueous Extract Induces Hepatocellular Carcinoma Cell Apoptosis via Caspase-Dependent Mitochondrial Pathway. Biomed Res Int 2016:9014364 (2016). WB . PubMed: 28018916
  • Yan Y  et al. Ras-related associated with diabetes gene acts as a suppressor and inhibits Warburg effect in hepatocellular carcinoma. Onco Targets Ther 9:3925-37 (2016). IHC . PubMed: 27418837
  • Ganz M  et al. Progression of non-alcoholic steatosis to steatohepatitis and fibrosis parallels cumulative accumulation of danger signals that promote inflammation and liver tumors in a high fat-cholesterol-sugar diet model in mice. J Transl Med 13:193 (2015). PubMed: 26077675
  • Chen X  et al. Downregulation of microRNA-146a inhibits ovarian granulosa cell apoptosis by simultaneously targeting interleukin-1 receptor-associated kinase and tumor necrosis factor receptor-associated factor 6. Mol Med Rep 12:5155-62 (2015). PubMed: 26151128
  • Sanchez-Niño MD  et al. Albumin-induced apoptosis of tubular cells is modulated by BASP1. Cell Death Dis 6:e1644 (2015). WB ; Human . PubMed: 25675304
  • Skrzypek K  et al. Constitutive activation of MET signaling impairs myogenic differentiation of rhabdomyosarcoma and promotes its development and progression. Oncotarget 6:31378-98 (2015). IHC-P . PubMed: 26384300
  • Zhang P  et al. Antitumor effects of pharmacological EZH2 inhibition on malignant peripheral nerve sheath tumor through the miR-30a and KPNB1 pathway. Mol Cancer 14:55 (2015). PubMed: 25890085
  • Chopra M  et al. Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GVHD. Blood 126:437-44 (2015). PubMed: 26012567
  • Tahiri A  et al. Deregulation of cancer-related miRNAs is a common event in both benign and malignant human breast tumors. Carcinogenesis 35:76-85 (2014). ICC/IF ; Human . PubMed: 24104550
  • Tarín C  et al. Tumor necrosis factor-like weak inducer of apoptosis or Fn14 deficiency reduce elastase perfusion-induced aortic abdominal aneurysm in mice. J Am Heart Assoc 3:N/A (2014). PubMed: 25092786
  • Van Looy T  et al. Characterization and assessment of the sensitivity and resistance of a newly established human gastrointestinal stromal tumour xenograft model to treatment with tyrosine kinase inhibitors. Clin Sarcoma Res 4:10 (2014). IHC-P ; Human . PubMed: 25132955
  • Steffensen MA  et al. Suppressors of cytokine signaling 1 and 3 are upregulated in brain resident cells in response to virus-induced inflammation of the central nervous system via at least two distinctive pathways. J Virol 88:14090-104 (2014). IHC (PFA fixed) ; Mouse . PubMed: 25253351
  • Urbanik T  et al. CYLD deletion triggers nuclear factor-?B-signaling and increases cell death resistance in murine hepatocytes. World J Gastroenterol 20:17049-64 (2014). IHC-P ; Mouse . PubMed: 25493017
  • Zhang P  et al. EZH2-miR-30d-KPNB1 pathway regulates malignant peripheral nerve sheath tumour cell survival and tumourigenesis. J Pathol 232:308-18 (2014). PubMed: 24132643
  • Hongisto V  et al. The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells - A data description. Genom Data 2:249-53 (2014). PubMed: 26484103
  • Hegde VR  et al. Glia are critical for the neuropathology of complex I deficiency in Drosophila. Hum Mol Genet 23:4686-92 (2014). PubMed: 24760769
  • Aure MR  et al. Individual and combined effects of DNA methylation and copy number alterations on miRNA expression in breast tumors. Genome Biol 14:R126 (2013). PubMed: 24257477
  • Pachel C  et al. Exogenous Administration of a Recombinant Variant of TWEAK Impairs Healing after Myocardial Infarction by Aggravation of Inflammation. PLoS One 8:e78938 (2013). IHC-P ; Mouse . PubMed: 24244389
  • Sharifi R  et al. Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease. EMBO J 32:1225-37 (2013). PubMed: 23481255
  • Sánchez-Alvarez R  et al. Ethanol diverts early neuronal differentiation trajectory of embryonic stem cells by disrupting the balance of lineage specifiers. PLoS One 8:e63794 (2013). Mouse . PubMed: 23724002
  • Melis MH  et al. Sustained tumour eradication after induced caspase-3 activation and synchronous tumour apoptosis requires an intact host immune response. Cell Death Differ 20:765-73 (2013). Mouse . PubMed: 23412345
  • Brunetto E  et al. CDC25A protein stability represents a previously unrecognized target of HER2 signaling in human breast cancer: implication for a potential clinical relevance in trastuzumab treatment. Neoplasia 15:579-90 (2013). WB . PubMed: 23730206
  • Leivonen SK  et al. High-throughput screens identify microRNAs essential for HER2 positive breast cancer cell growth. Mol Oncol N/A:N/A (2013). Human . PubMed: 24148764
  • Sahlberg KK  et al. The HER2 amplicon includes several genes required for the growth and survival of HER2 positive breast cancer cells. Mol Oncol 7:392-401 (2013). PubMed: 23253899
  • Betton B  et al. Influence of pH on the Cytotoxic Activity of Inositol Hexakisphosphate (IP6) in Prostate Cancer. Front Oncol 1:40 (2011). PubMed: 22655245
  • Mitra M  et al. Enhanced in vitro antiproliferative effects of EpCAM antibody-functionalized paclitaxel-loaded PLGA nanoparticles in retinoblastoma cells. Mol Vis 17:2724-37 (2011). Flow Cyt ; Human . PubMed: 22065926
  • Mitra M  et al. Reversal of stathmin-mediated microtubule destabilization sensitizes retinoblastoma cells to a low dose of antimicrotubule agents: a novel synergistic therapeutic intervention. Invest Ophthalmol Vis Sci 52:5441-8 (2011). PubMed: 21546534
  • Demers M  et al. Overexpression of galectin-7, a myoepithelial cell marker, enhances spontaneous metastasis of breast cancer cells. Am J Pathol 176:3023-31 (2010). PubMed: 20382700
  • Rodrigues P  et al. Multiple mechanisms of germ cell loss in the perinatal mouse ovary. Reproduction 137:709-20 (2009). PubMed: 19176312
  • Iljin K  et al. High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. Clin Cancer Res 15:6070-8 (2009). WB ; Human . PubMed: 19789329
  • Bai Y  et al. An Ang1-Tie2-PI3K axis in neural progenitor cells initiates survival responses against oxygen and glucose deprivation. Neuroscience 160:371-81 (2009). PubMed: 19409199
  • Dittmer A  et al. Human mesenchymal stem cells induce E-cadherin degradation in breast carcinoma spheroids by activating ADAM10. Cell Mol Life Sci 66:3053-65 (2009). PubMed: 19603142
  • Simonsson M  et al. Low-dose hypersensitive gammaH2AX response and infrequent apoptosis in epidermis from radiotherapy patients. Radiother Oncol 88:388-97 (2008). PubMed: 18524402

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