Overview

  • Product name

    Anti-CLEC-2 antibody [17D9]
    See all CLEC-2 primary antibodies
  • Description

    Rat monoclonal [17D9] to CLEC-2
  • Host species

    Rat
  • Tested applications

    Suitable for: WB, Flow Cytmore details
  • Species reactivity

    Reacts with: Mouse
  • Immunogen

    Tissue, cells or virus corresponding to Mouse CLEC-2.

Properties

Applications

Our Abpromise guarantee covers the use of ab90542 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 20 kDa.
Flow Cyt Use at an assay dependent concentration.

ab18536 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody.

 

Target

  • Function

    Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.
  • Tissue specificity

    Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.
  • Sequence similarities

    Contains 1 C-type lectin domain.
  • Post-translational
    modifications

    Glycosylated.
    Phosphorylated on tyrosine residue in response to rhodocytin binding.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 1810061I13Rik antibody
    • C type lectin domain family 1 member B antibody
    • C type lectin like receptor 2 antibody
    • C-type lectin domain family 1 member B antibody
    • C-type lectin domain family 1, member B antibody
    • C-type lectin-like receptor 2 antibody
    • C-type lectin-like receptor-2 antibody
    • CLC1B_HUMAN antibody
    • CLEC 2 antibody
    • CLEC 2B antibody
    • CLEC-2 antibody
    • CLEC1B antibody
    • CLEC2 antibody
    • CLEC2B antibody
    • PRO1384 antibody
    • QDED721 antibody
    see all

Images

References

This product has been referenced in:

  • Kerrigan AM  et al. CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. J Immunol 182:4150-7 (2009). Read more (PubMed: 19299712) »
See 1 Publication for this product

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