Key features and details
- Rat monoclonal [17D9] to CLEC-2
- Suitable for: WB, Flow Cyt
- Reacts with: Mouse
- Isotype: IgG2b
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
Storage bufferConstituent: PBS
Concentration information loading...
PurityProtein A/G purified
Our Abpromise guarantee covers the use of ab90542 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use at an assay dependent concentration. Predicted molecular weight: 20 kDa.|
|Flow Cyt||Use at an assay dependent concentration.
ab18536 - Rat monoclonal IgG2b, is suitable for use as an isotype control with this antibody.
FunctionActs as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.
Tissue specificityExpressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.
Sequence similaritiesContains 1 C-type lectin domain.
Phosphorylated on tyrosine residue in response to rhodocytin binding.
- Information by UniProt
- 1810061I13Rik antibody
- C type lectin domain family 1 member B antibody
- C type lectin like receptor 2 antibody
All lanes : Anti-CLEC-2 antibody [17D9] (ab90542)
Lane 1 : B3Z
Lane 2 : B3Z mCLEC-2
Predicted band size: 20 kDa
Observed band size: 25 kDa why is the actual band size different from the predicted?
ab90542 has been referenced in 1 publication.
- Kerrigan AM et al. CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. J Immunol 182:4150-7 (2009). PubMed: 19299712