Key features and details
- Rabbit polyclonal to CLEC-2
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-CLEC-2 antibody
See all CLEC-2 primary antibodies
DescriptionRabbit polyclonal to CLEC-2
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Recombinant full length protein corresponding to Human CLEC-2 aa 1-229.
MQDEDGYITLNIKTRKPALISVGSASSSWWRVMALILLILCVGMVVGLVA LGIWSVMQRNYLQGENENRTGTLQQLAKRFCQYVVKQSELKGTFKGHKCS PCDTNWRYYGDSCYGFFRHNLTWEESKQYCTDMNATLLKIDNRNIVEYIK ARTHLIRWVGLSRQKSNEVWKWEDGSVISENMFEFLEDGKGNMNCAYFHN GKMHPTFCENKHYLMCERKAGMTKVDQLP
Database link: Q9P126
- Human liver cancer tissue.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab197349 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/10 - 1/50.|
FunctionActs as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets.
Tissue specificityExpressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets.
Sequence similaritiesContains 1 C-type lectin domain.
Phosphorylated on tyrosine residue in response to rhodocytin binding.
- Information by UniProt
- 1810061I13Rik antibody
- C type lectin domain family 1 member B antibody
- C type lectin like receptor 2 antibody
ab197349 has been referenced in 1 publication.
- Hu K et al. CLEC1B Expression and PD-L1 Expression Predict Clinical Outcome in Hepatocellular Carcinoma with Tumor Hemorrhage. Transl Oncol 11:552-558 (2018). PubMed: 29525632