Key features and details
- Rabbit polyclonal to CLEC12A
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-CLEC12A antibody
See all CLEC12A primary antibodies
DescriptionRabbit polyclonal to CLEC12A
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Recombinant fragment corresponding to Human CLEC12A aa 66-265.
Database link: Q5QGZ9
- IHC-P: Human tonsil and spleen tissues.
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Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab238687 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||1/20 - 1/200.|
FunctionCell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
Tissue specificityDetected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.
Sequence similaritiesContains 1 C-type lectin domain.
DomainContains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
modificationsHighly N-glycosylated. Glycosylation varies between cell types.
Cellular localizationCell membrane. Ligand binding leads to internalization.
- Information by UniProt
- C-type lectin domain family 12 member A antibody
- C-type lectin-like molecule 1 antibody
- CL12A_HUMAN antibody
Paraffin-embedded human tonsil tissue stained for CLEC12A using ab238687 at 1/100 dilution in immunohistochemical analysis. Heat-mediated antigen retrieval was performed with sodium citrate buffer.
Paraffin-embedded human spleen tissue stained for CLEC12A using ab238687 at 1/100 dilution in immunohistochemical analysis. Heat-mediated antigen retrieval was performed with sodium citrate buffer.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab238687 has not yet been referenced specifically in any publications.