Overview

  • Product name

  • Description

    Rabbit polyclonal to CLEC12A
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human CLEC12A aa 66-265.
    Database link: Q5QGZ9

  • Positive control

    • IHC-P: Human tonsil and spleen tissues.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 50% Glycerol, PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab238687 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/20 - 1/200.

Target

  • Function

    Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
  • Tissue specificity

    Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.
  • Sequence similarities

    Contains 1 C-type lectin domain.
  • Domain

    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Post-translational
    modifications

    Highly N-glycosylated. Glycosylation varies between cell types.
  • Cellular localization

    Cell membrane. Ligand binding leads to internalization.
  • Information by UniProt
  • Database links

  • Alternative names

    • C-type lectin domain family 12 member A antibody
    • C-type lectin-like molecule 1 antibody
    • CL12A_HUMAN antibody
    • CLEC12A antibody
    • CLL-1 antibody
    • DCAL-2 antibody
    • Dendritic cell-associated lectin 2 antibody
    • MICL antibody
    • Myeloid inhibitory C-type lectin-like receptor antibody
    see all

Images

  • Paraffin-embedded human tonsil tissue stained for CLEC12A using ab238687 at 1/100 dilution in immunohistochemical analysis.

  • Paraffin-embedded human spleen tissue stained for CLEC12A using ab238687 at 1/100 dilution in immunohistochemical analysis.

References

ab238687 has not yet been referenced specifically in any publications.

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