Key features and details
- Goat polyclonal to CLEC12A - C-terminal
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-CLEC12A antibody - C-terminal
See all CLEC12A primary antibodies
DescriptionGoat polyclonal to CLEC12A - C-terminal
Specificityab193941 is expected to recognize all reported isoforms (NP_612210.4; NP_963917.2; NP_001193939.1).
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
- U937 cell line lysate.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 99% Tris buffered saline, 0.5% BSA
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab193941 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Our Abpromise guarantee covers the use of ab193941 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 0.3 - 1 µg/ml. Detects a band of approximately 37 kDa (predicted molecular weight: 30 kDa).
1 hour primary incubation is recommended for this product.
FunctionCell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
Tissue specificityDetected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.
Sequence similaritiesContains 1 C-type lectin domain.
DomainContains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
modificationsHighly N-glycosylated. Glycosylation varies between cell types.
Cellular localizationCell membrane. Ligand binding leads to internalization.
- Information by UniProt
- C-type lectin domain family 12 member A antibody
- C-type lectin-like molecule 1 antibody
- CL12A_HUMAN antibody
ab193941 has not yet been referenced specifically in any publications.