Anti-CLEC-2 antibody [17D9] (ab90542)
Key features and details
- Rat monoclonal [17D9] to CLEC-2
- Suitable for: WB
- Reacts with: Mouse
- Isotype: IgG2b
Overview
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Product name
Anti-CLEC-2 antibody [17D9]
See all CLEC-2 primary antibodies -
Description
Rat monoclonal [17D9] to CLEC-2 -
Host species
Rat -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Mouse -
Immunogen
Tissue, cells or virus. This information is proprietary to Abcam and/or its suppliers.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
Preservative: 0.02% Sodium azide
Constituent: 99.98% PBS -
Concentration information loading...
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Purity
Protein A/G purified -
Clonality
Monoclonal -
Clone number
17D9 -
Myeloma
Y3/Ag1.2.3 -
Isotype
IgG2b -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab90542 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
WB |
Use at an assay dependent concentration. Predicted molecular weight: 20 kDa.
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Notes |
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WB
Use at an assay dependent concentration. Predicted molecular weight: 20 kDa. |
Target
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Function
Acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding leads to tyrosine phosphorylation and this promotes the binding of spleen tyrosine kinase (Syk) and initiation of downstream tyrosine phosphorylation events and activation of PLC-gamma-2. Acts as an attachment factor for human immunodeficiency virus type 1 (HIV-1) and facilitates its capture by platelets. -
Tissue specificity
Expressed preferentially in the liver. Also expressed in immune cells of myeloid origin and on the surface of platelets. -
Sequence similarities
Contains 1 C-type lectin domain. -
Post-translational
modificationsGlycosylated.
Phosphorylated on tyrosine residue in response to rhodocytin binding. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 56760 Mouse
- SwissProt: Q9JL99 Mouse
- Unigene: 30700 Mouse
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Alternative names
- 1810061I13Rik antibody
- C type lectin domain family 1 member B antibody
- C type lectin like receptor 2 antibody
see all
Images
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All lanes : Anti-CLEC-2 antibody [17D9] (ab90542)
Lane 1 : B3Z
Lane 2 : B3Z mCLEC-2
Predicted band size: 20 kDa
Observed band size: 25 kDa why is the actual band size different from the predicted?
Datasheets and documents
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SDS download
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Datasheet download
References (1)
ab90542 has been referenced in 1 publication.
- Kerrigan AM et al. CLEC-2 is a phagocytic activation receptor expressed on murine peripheral blood neutrophils. J Immunol 182:4150-7 (2009). PubMed: 19299712