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  1. Link

    clec4d-antibody-ab175021.pdf

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Immunology Innate Immunity Macrophage / Inflamm.
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Anti-CLEC4D antibody (ab175021)

  • Datasheet
  • SDS
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Western blot - Anti-CLEC4D antibody (ab175021)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLEC4D antibody (ab175021)

Key features and details

  • Rabbit polyclonal to CLEC4D
  • Suitable for: IHC-P, WB
  • Reacts with: Human
  • Isotype: IgG

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Overview

  • Product name

    Anti-CLEC4D antibody
  • Description

    Rabbit polyclonal to CLEC4D
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant full length protein corresponding to Human CLEC4D.
    Database link: Q8WXI8

  • Positive control

    • 293T cell extract; Human liver cancer tissue.
  • General notes

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 50% Glycerol, 49% PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Immunology
    • Innate Immunity
    • Macrophage / Inflamm.

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

Applications

The Abpromise guarantee

Our Abpromise guarantee covers the use of ab175021 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
1/50 - 1/200.
WB
1/500 - 1/2000. Predicted molecular weight: 25 kDa.
Notes
IHC-P
1/50 - 1/200.
WB
1/500 - 1/2000. Predicted molecular weight: 25 kDa.

Target

  • Function

    Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells.
  • Tissue specificity

    Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma.
  • Sequence similarities

    Contains 1 C-type lectin domain.
  • Cellular localization

    Membrane.
  • Target information above from: UniProt accession Q8WXI8 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt
  • Database links

    • Entrez Gene: 338339 Human
    • Omim: 609964 Human
    • SwissProt: Q8WXI8 Human
    • Unigene: 351811 Human
    • Alternative names

      • C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 8 antibody
      • C type lectin domain family 4, member D antibody
      • C type lectin like receptor 6 antibody
      • C type lectin receptor antibody
      • C type lectin superfamily member 8 antibody
      • C-type lectin domain family 4 member D antibody
      • C-type lectin superfamily member 8 antibody
      • C-type lectin-like receptor 6 antibody
      • CLC4D_HUMAN antibody
      • CLEC 6 antibody
      • CLEC-6 antibody
      • Clec4d antibody
      • CLEC6 antibody
      • CLECSF8 antibody
      • lectin, C type, superfamily member 8 antibody
      • Macrophage C type lectin antibody
      • MCL antibody
      • MGC40078 antibody
      • MPCL antibody
      see all

    Images

    • Western blot - Anti-CLEC4D antibody (ab175021)
      Western blot - Anti-CLEC4D antibody (ab175021)
      Anti-CLEC4D antibody (ab175021) at 1/500 dilution + 293T cell extract

      Predicted band size: 25 kDa

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLEC4D antibody (ab175021)
      Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLEC4D antibody (ab175021)

      Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling CLEC4D with ab175021 at 1/50 dilution.

    Protocols

    • Western blot protocols
    • Immunohistochemistry protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (1)

    Publishing research using ab175021? Please let us know so that we can cite the reference in this datasheet.

    ab175021 has been referenced in 1 publication.

    • N'diaye M  et al. C-type lectin receptors Mcl and Mincle control development of multiple sclerosis-like neuroinflammation. J Clin Invest 130:838-852 (2020). PubMed: 31725411

    Customer reviews and Q&As

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    Please use the links above to contact us or submit feedback about this product.

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