Anti-CLEC4D antibody (ab175021)
Key features and details
- Rabbit polyclonal to CLEC4D
- Suitable for: IHC-P, WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-CLEC4D antibody -
Description
Rabbit polyclonal to CLEC4D -
Host species
Rabbit -
Tested applications
Suitable for: IHC-P, WBmore details -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length protein corresponding to Human CLEC4D.
Database link: Q8WXI8 -
Positive control
- 293T cell extract; Human liver cancer tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 49% PBS -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab175021 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P |
1/50 - 1/200.
|
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| WB |
1/500 - 1/2000. Predicted molecular weight: 25 kDa.
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| Notes |
|---|
|
IHC-P
1/50 - 1/200. |
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WB
1/500 - 1/2000. Predicted molecular weight: 25 kDa. |
Target
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Function
Functions as an endocytic receptor. May be involved in antigen uptake at the site of infection, either for clearance of the antigen, or for processing and further presentation to T cells. -
Tissue specificity
Expressed weakly in peripheral blood leukocytes, bone marrow and spleen. Expression is confined mostly in monocytes and macrophage and seems to be up-regulated by IL-6, IL-10, TNF-alpha and IFN-gamma. -
Sequence similarities
Contains 1 C-type lectin domain. -
Cellular localization
Membrane. - Information by UniProt
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Database links
- Entrez Gene: 338339 Human
- Omim: 609964 Human
- SwissProt: Q8WXI8 Human
- Unigene: 351811 Human
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Alternative names
- C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 8 antibody
- C type lectin domain family 4, member D antibody
- C type lectin like receptor 6 antibody
see all
Images
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Western blot - Anti-CLEC4D antibody (ab175021)Anti-CLEC4D antibody (ab175021) at 1/500 dilution + 293T cell extract
Predicted band size: 25 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLEC4D antibody (ab175021)Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling CLEC4D with ab175021 at 1/50 dilution.
Protocols
Datasheets and documents
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Datasheet download
References (1)
ab175021 has been referenced in 1 publication.
- N'diaye M et al. C-type lectin receptors Mcl and Mincle control development of multiple sclerosis-like neuroinflammation. J Clin Invest 130:838-852 (2020). PubMed: 31725411
