Overview

  • Product name

    Anti-CLECSF6 antibody
  • Description

    Rabbit polyclonal to CLECSF6
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 34-219 of Human CLECSF6 (UniProt Q9UMR7).

  • Positive control

    • H1299 whole cell lysate; HCT116 cell lysate; CL1-5 xenograft
  • General notes

    Store undiluted.

Properties

Applications

Our Abpromise guarantee covers the use of ab127025 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 28 kDa.
IHC-P 1/100 - 1/500. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.
  • Tissue specificity

    Expressed in dendritic cells, myeloid cells, B-cells and HL-60 cells (at protein level). TNF alpha, IL-1 alpha, and LPS, down-regulated expression at the surface of neutrophils (at protein level). Expressed preferentially in hematopoietic tissues. Expressed in peripheral blood leukocytes, neutrophils, moderate quantities in spleen, lymph node, and bone marrow, and at very low levels in thymus. Expressed in Ag-presenting cells (DC, monocytes, macrophages and B-cells), as well as on granulocytes. Expression was decreased in DC by signals inducing its maturation (e.g. CD40 ligand, LPS, and TNF alpha).
  • Sequence similarities

    Contains 1 C-type lectin domain.
  • Domain

    Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 6 antibody
    • C type lectin antibody
    • C type lectin DDB27 antibody
    • C type lectin superfamily 6 antibody
    • C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 6 antibody
    • C-type lectin superfamily member 6 antibody
    • C-type lectin DDB27 antibody
    • C-type lectin domain family 4 member A antibody
    • C-type lectin domain family 4, member A antibody
    • C-type lectin domain family 4, member a2 antibody
    • C-type lectin superfamily member 6 antibody
    • CLC4A_HUMAN antibody
    • Clec4a antibody
    • Clec4a2 antibody
    • CLECSF6 antibody
    • DCIR antibody
    • Dcir1 antibody
    • DDB27 antibody
    • Dendritic cell immunoreceptor antibody
    • HDCGC13P antibody
    • Lectin like immunoreceptor antibody
    • Lectin, C-type, superfamily member 6 antibody
    • Lectin-like immunoreceptor antibody
    • LLIR antibody
    see all

Images

  • Anti-CLECSF6 antibody (ab127025) at 1/1000 dilution + H1299 whole cell
    lysate at 30 µg

    Predicted band size: 28 kDa



    12% SDS PAGE
  • ab127025, at 1/500 dilution, staining CLECSF6 in paraffin-embedded CL1-5 xenograft by Immunohistochemistry.

References

ab127025 has not yet been referenced specifically in any publications.

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