Overview

  • Product name

    Clemastine Fumarate, H1 receptor antagonist
  • Description

    Potent and selective H1 receptor antagonist. Potent HERG K+ channel inhibitor.
  • Biological description

    Potent and selective H1 receptor antagonist (IC50 = 3 nM). Potent HERG K+ channel inhibitor (IC50 = 12 nM). Allosteric modulator of P2X7. Shows immunosuppressant effects in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    14976-57-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Nörenberg W  et al. Clemastine potentiates the human P2X7 receptor by sensitizing it to lower ATP concentrations. J Biol Chem 286:11067-81 (2011). Read more (PubMed: 21262970) »
  • Johansen P  et al. Clemastine causes immune suppression through inhibition of extracellular signal-regulated kinase-dependent proinflammatory cytokines. J Allergy Clin Immunol 128:1286-94 (2011). Read more (PubMed: 21807405) »
  • Ridley JM  et al. Clemastine, a conventional antihistamine, is a high potency inhibitor of the HERG K+ channel. J Mol Cell Cardiol 40:107-18 (2006). Read more (PubMed: 16288909) »

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