Overview

  • Product name

    Anti-CLIC6 antibody
  • Description

    Rabbit polyclonal to CLIC6
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to Human CLIC6 aa 455-480.
    Sequence:

    LFVKVKLTALGCSRIAIKKYLRAGYD


    Database link: Q96NY7

  • Positive control

    • Human pancreas tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab204566 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport.
  • Tissue specificity

    Expressed in brain, placenta, pancreas and liver.
  • Sequence similarities

    Belongs to the chloride channel CLIC family.
    Contains 1 GST C-terminal domain.
  • Domain

    Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.
  • Post-translational
    modifications

    Phosphorylated.
  • Cellular localization

    Cytoplasm. Cell membrane. Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Chloride channel form A antibody
    • Chloride intracellular channel 6 antibody
    • Chloride intracellular channel protein 6 antibody
    • CLIC1L antibody
    • Clic6 antibody
    • CLIC6_HUMAN antibody
    • Parchorin antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed paraffin-embedded Human pancreas tissue labeling CLIC6 with ab204566 at 1/50.

References

ab204566 has not yet been referenced specifically in any publications.

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