Overview

  • Product name

    Clindamycin, inhibits protein synthesis
  • Description

    Broad spectrum antimicrobial activity
  • Alternative names

    • 18323-44-9
    • Cleocin
  • Biological description

    Broad spectrum antimicrobial agent. Active against Gram-positive and Gram-negative bacteria and selected protozoa. Competitive inhibitor of peptide formation in large 50S ribosomal unit. Orally active in vivo.
  • Purity

    > 99%
  • CAS Number

    18323-44-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S,4R)-N-[(1S,2S)-2-Chloro-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methylsulfanyloxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide
  • Molecular weight

    424.98
  • Molecular formula

    C18H33ClN2O5S
  • PubChem identifier

    446598
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in 1 eq HCl to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)O)O)O)C(C)Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Guay D Update on clindamycin in the management of bacterial, fungal and protozoal infections. Expert Opin Pharmacother 8:2401-44 (2007). Read more (PubMed: 17927492) »
  • Kouvela EC  et al. Unraveling new features of clindamycin interaction with functional ribosomes and dependence of the drug potency on polyamines. J Biol Chem 281:23103-10 (2006). Read more (PubMed: 16760473) »
  • Leigh DA Antibacterial activity and pharmacokinetics of clindamycin. J Antimicrob Chemother 7 Suppl A:3-9 (1981). Read more (PubMed: 7019193) »
  • Cullmann W  et al. Antibacterial activity of oral antibiotics against anaerobic bacteria. Chemotherapy 39:169-74 (0). Read more (PubMed: 8508686) »

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