Overview

  • Product name

  • Description

    Rabbit polyclonal to CLK4
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide within Human CLK4 aa 70-150. The exact sequence is proprietary.
    Database link: Q9HAZ1

  • Positive control

    • IHC-P: Human spleen tissue. WB: HT-29 cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab230632 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 57 kDa.
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
  • Tissue specificity

    Expressed in liver, kidney, heart, muscle, brain and endothelial cells.
  • Sequence similarities

    Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.
    Contains 1 protein kinase domain.
  • Post-translational
    modifications

    Autophosphorylates on all three types of residues.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • AI987988 antibody
    • C85119 antibody
    • CDC like kinase 4 antibody
    • CDC-like kinase 4 antibody
    • CLK4 antibody
    • CLK4_HUMAN antibody
    • DKFZp686A20267 antibody
    • Dual specificity protein kinase CLK4 antibody
    • OTTMUSP00000005756; antibody
    • OTTMUSP00000005757 antibody
    • OTTMUSP00000041113 antibody
    • Protein serine threonine kinase Clk4 antibody
    • RP23-9N7.1 antibody
    see all

Images

  • Formalin-fixed, paraffin-embedded human spleen tissue stained for CLK4 using ab230632 at 5 µg/ml in immunohistochemical analysis.

  • Anti-CLK4 antibody (ab230632) at 1/500 dilution + HT-29 (human colorectal adenocarcinoma cell line) whole cell lysate

    Predicted band size: 57 kDa

References

ab230632 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab230632.
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