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  1. Link

    clld8setdb2-antibody-ab56184.pdf

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Epigenetics and Nuclear Signaling Chromatin Modifying Enzymes Methylation
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Anti-CLLD8/SETDB2 antibody (ab56184)

  • Datasheet
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Key features and details

  • Rabbit polyclonal to CLLD8/SETDB2
  • Reacts with: Human
  • Isotype: IgG

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Secondary
Product image
Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

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Overview

  • Product name

    Anti-CLLD8/SETDB2 antibody
    See all CLLD8/SETDB2 primary antibodies
  • Description

    Rabbit polyclonal to CLLD8/SETDB2
  • Host species

    Rabbit
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human CLLD8/SETDB2 (N terminal).
    Database link: Q96T68

  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage buffer

    pH: 7.2
    Preservative: 0.01% Sodium azide
    Constituents: 50% Glycerol (glycerin, glycerine), PBS
  • Concentration information loading...
  • Purity

    Immunogen affinity purified
  • Clonality

    Polyclonal
  • Isotype

    IgG
  • Research areas

    • Epigenetics and Nuclear Signaling
    • Chromatin Modifying Enzymes
    • Methylation
    • Epigenetics and Nuclear Signaling
    • Chromatin Modifying Enzymes
    • Methylation
    • Lysine methylation

Associated products

  • Compatible Secondaries

    • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
    • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
  • Isotype control

    • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
  • Recombinant Protein

    • Recombinant Human CLLD8/SETDB2 protein (ab169554)

Applications

  • Application notes
    ELISA: Use at an assay dependent dilution.
    WB: Use at a concentration of 1 µg/ml for 2hrs. Predicted molecular weight: 82 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function

      Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.
    • Tissue specificity

      Ubiquitous. Highest expression in heart, testis and ovary.
    • Sequence similarities

      Belongs to the histone-lysine methyltransferase family.
      Contains 1 MBD (methyl-CpG-binding) domain.
      Contains 1 pre-SET domain.
      Contains 1 SET domain.
    • Cellular localization

      Nucleus. Chromosome.
    • Target information above from: UniProt accession Q96T68 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 83852 Human
      • Omim: 607865 Human
      • SwissProt: Q96T68 Human
      • Unigene: 631789 Human
      • Alternative names

        • C13orf4 antibody
        • Chromosome 13 open reading frame 4 antibody
        • Chronic lymphocytic leukemia deletion region 8 antibody
        • Chronic lymphocytic leukemia deletion region gene 8 antibody
        • Chronic lymphocytic leukemia deletion region gene 8 protein antibody
        • Clld8 antibody
        • CLLL8 antibody
        • Gm293 antibody
        • H3-K9-HMTase antibody
        • Histone H3-K9 methyltransferase antibody
        • Histone-lysine N-methyltransferase SETDB2 antibody
        • KMT1F antibody
        • Lysine N-methyltransferase 1F antibody
        • Probable histone-lysine N-methyltransferase H3 lysine-9 specific antibody
        • SEB2 antibody
        • SET domain bifurcated 2 antibody
        • SET domain protein, bifurcated, 2 antibody
        • SETB2_HUMAN antibody
        • Setdb2 antibody
        see all

      Protocols

      • Western blot protocols

      Click here to view the general protocols

      Datasheets and documents

      • Datasheet
    • References (1)

      Publishing research using ab56184? Please let us know so that we can cite the reference in this datasheet.

      ab56184 has been referenced in 1 publication.

      • Falandry C  et al. CLLD8/KMT1F is a lysine methyltransferase that is important for chromosome segregation. J Biol Chem 285:20234-41 (2010). WB, ICC/IF ; Human . PubMed: 20404330

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