Key features and details
- Rabbit polyclonal to CLLD8/SETDB2
- Reacts with: Human
- Isotype: IgG
Product nameAnti-CLLD8/SETDB2 antibody
See all CLLD8/SETDB2 primary antibodies
DescriptionRabbit polyclonal to CLLD8/SETDB2
Species reactivityReacts with: Human
Synthetic peptide corresponding to Human CLLD8/SETDB2 (N terminal).
Database link: Q96T68
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), PBS
Concentration information loading...
PurityImmunogen affinity purified
WB: Use at a concentration of 1 µg/ml for 2hrs. Predicted molecular weight: 82 kDa.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
FunctionHistone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.
Tissue specificityUbiquitous. Highest expression in heart, testis and ovary.
Sequence similaritiesBelongs to the histone-lysine methyltransferase family.
Contains 1 MBD (methyl-CpG-binding) domain.
Contains 1 pre-SET domain.
Contains 1 SET domain.
Cellular localizationNucleus. Chromosome.
- Information by UniProt
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ab56184 has been referenced in 1 publication.
- Falandry C et al. CLLD8/KMT1F is a lysine methyltransferase that is important for chromosome segregation. J Biol Chem 285:20234-41 (2010). WB, ICC/IF ; Human . PubMed: 20404330