Overview

  • Product name

    Anti-CLNS1A/CLCI antibody [2187C2a]
    See all CLNS1A/CLCI primary antibodies
  • Description

    Mouse monoclonal [2187C2a] to CLNS1A/CLCI
  • Host species

    Mouse
  • Tested applications

    Suitable for: Dot blot, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment corresponding to CLNS1A/CLCI (C terminal).

  • General notes

     This product was previously labelled as CLNS1A

     

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
  • Storage buffer

    pH: 7.40
    Preservative: 0.05% Sodium azide
    Constituents: 0.0225% Potassium chloride, 0.0204% Monobasic dihydrogen potassium phosphate, 0.1136% Dibasic monohydrogen sodium phosphate, 1% BSA, 0.03% Potassium phosphate, 0.812% Sodium chloride, 0.1312% Sodium phosphate
  • Concentration information loading...
  • Purity

    Protein G purified
  • Purification notes

    ab53667 was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
  • Clonality

    Monoclonal
  • Clone number

    2187C2a
  • Isotype

    IgG1
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab53667 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Dot blot Use at an assay dependent dilution.
WB Use at an assay dependent dilution. Predicted molecular weight: 26 kDa.

Target

  • Function

    The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.
  • Sequence similarities

    Belongs to the pICln family.
  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Cytoplasm. Nucleus. Cytoplasm > cytoskeleton. A small fraction is also associated with the cytoskeleton.
  • Information by UniProt
  • Database links

  • Alternative names

    • Chloride channel antibody
    • Chloride channel nucleotide sensitive 1A antibody
    • Chloride channel regulatory protein antibody
    • Chloride conductance regulator, volume sensitive antibody
    • Chloride conductance regulatory protein ICln antibody
    • Chloride ion current inducer protein antibody
    • ClCI antibody
    • CLNS 1A antibody
    • Clns1a antibody
    • CLNS1B antibody
    • I(Cln) antibody
    • ICln antibody
    • ICLN_HUMAN antibody
    • Methylosome subunit pICln antibody
    • nucleotide sensitive 1A antibody
    • Reticulocyte pICln antibody
    • Reticulocyte protein ICln antibody
    see all

Images

References

ab53667 has not yet been referenced specifically in any publications.

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