Overview

  • Product name

    Anti-CLNS1A/CLCI antibody - C-terminal
    See all CLNS1A/CLCI primary antibodies
  • Description

    Rabbit polyclonal to CLNS1A/CLCI - C-terminal
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide corresponding to Human CLNS1A/CLCI (C terminal).
    Database link: P54105

  • Positive control

    • HuvEc, K562, HeLa, HepG2, A549 and Jurkat cell extracts.
  • General notes

     This product was previously labelled as CLNS1A

     

Properties

Applications

Our Abpromise guarantee covers the use of ab196744 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 26 kDa.

Target

  • Function

    The interaction with Sm proteins inhibits their assembly on U RNA and interferes with snRNP biogenesis. Inhibits the binding of survival motor neuron protein (SMN) to Sm proteins. May participate in cellular volume control by activation of a swelling-induced chloride conductance pathway.
  • Sequence similarities

    Belongs to the pICln family.
  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

    Cytoplasm. Nucleus. Cytoplasm > cytoskeleton. A small fraction is also associated with the cytoskeleton.
  • Information by UniProt
  • Database links

  • Alternative names

    • Chloride channel antibody
    • Chloride channel nucleotide sensitive 1A antibody
    • Chloride channel regulatory protein antibody
    • Chloride conductance regulator, volume sensitive antibody
    • Chloride conductance regulatory protein ICln antibody
    • Chloride ion current inducer protein antibody
    • ClCI antibody
    • CLNS 1A antibody
    • Clns1a antibody
    • CLNS1B antibody
    • I(Cln) antibody
    • ICln antibody
    • ICLN_HUMAN antibody
    • Methylosome subunit pICln antibody
    • nucleotide sensitive 1A antibody
    • Reticulocyte pICln antibody
    • Reticulocyte protein ICln antibody
    see all

Images

  • All lanes : Anti-CLNS1A/CLCI antibody - C-terminal (ab196744) at 1/500 dilution

    Lane 1 : HepG2 cell extract
    Lane 2 : Jurkat cell extract
    Lane 3 : K562 cell extract
    Lane 4 : A549 cell extract
    Lane 5 : HuvEc cell extract
    Lane 6 : HeLa cell extract
    Lane 7 : HeLa cell extract with synthesized peptide

    Predicted band size: 26 kDa

References

ab196744 has not yet been referenced specifically in any publications.

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