Overview

  • Product name

    Clodronate disodium, ATP-ADP transporter inhibitor
  • Description

    ATP-ADP transporter inhibitor
  • Biological description

    ATP-ADP transporter inhibitor. Inhibits bone resorption and soft tissue calcification. Encapsulated in liposomes, depletes macrophages in vivo. Induces apoptosis in osteoclasts.
  • Purity

    > 98%
  • CAS Number

    22560-50-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [Dichloro[hydroxy(oxido)phosphoryl]methyl]hydroxyphosphinate disodium salt tetrahydrate
  • Molecular weight

    360.92
  • Molecular formula

    CH2Cl2Na2O6P2.4H2O
  • PubChem identifier

    31195
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C(P(=O)(O)[O-])(P(=O)(O)[O-])(Cl)Cl.[Na+].[Na+]
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Matsushita Y  et al. Microglia Activation Precedes the Anti-Opioid BDNF and NMDA Receptor Mechanisms Underlying Morphine Analgesic Tolerance. Curr Pharm Des : (2013). Read more (PubMed: 23448475) »
  • Lehenkari PP  et al. Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite. Mol Pharmacol 61:1255-62 (2002). Read more (PubMed: 11961144) »
  • Fleisch H Mechanisms of action of the bisphosphonates. Medicina (B Aires) 57 Suppl 1:65-75 (1997). Read more (PubMed: 9567358) »

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