Key features and details
- Antimetabolite agent. Purine analogue.
- CAS Number: 123318-82-1
- Purity: > 98%
- Soluble in water to 10 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product nameClofarabine, Purine analogue
DescriptionAntimetabolite agent. Purine analogue.
Biological descriptionAntimetabolite agent. Purine analogue. Deoxycytidine kinase substrate. Competes with dATP for DNA polymerase-α and -ε. Potent ribonucleotide reductase inhibitor (IC50 = 65 nM). Induces apoptosis by directly altering mitochondrial transmembrane potential. Shows antitumor effects in vivo.
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 10 mM and in DMSO to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab142732 has not yet been referenced specifically in any publications.